Effect of aspirin on haloperidol-induced cataleptic behavior in mice
1988; Elsevier BV; Volume: 27; Issue: 3 Linguagem: Inglês
10.1016/0028-3908(88)90051-2
ISSN1873-7064
AutoresN. Ono, Ryo� Saito, Taira Abiru, Yasuhiro Matsushita, Hiro‐o Kamiya,
Tópico(s)Pharmacogenetics and Drug Metabolism
ResumoHaloperidol given intraperitoneally dose-dependently elicited cataleptic behavior, evaluated by high bar and four-cork tests, in mice. The haloperidol-induced cataleptic behavior was reduced dose-dependently after oral treatment with aspirin, a cyclooxygenase inhibitor. The intracerebroventricular administration of prostaglandin F2a produced cataleptic behavior of long duration determined by the high bar test. It is suggested that prostaglandins may participate in the induction of cataleptic behavior in part.
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