Synthesis of Cribrostatin 6 and Its Related Compounds
2006; Elsevier BV; Volume: 68; Issue: 3 Linguagem: Inglês
10.3987/com-06-10674
ISSN1881-0942
AutoresShinsuke Nakahara, Akinori Kubo, Yuzuru Mikami, Junji Ito,
Tópico(s)Marine Sponges and Natural Products
ResumoThe synthesis of cribrostatin 6 (1), which shows good biological activity as a dark blue cancer cells growth inhibitor and a number of pathogenic bacteria and fungi, was achieved in two steps from 1-acetylaminomethyl-5,7-diethoxy-8-hydroxy-6-methylisoquinoline ( 14).The related compounds (8~11) were also synthesized, and the antimicrobial activities of 1 and its nine
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