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Asymptomatic Idiopathic Syndrome of Prolonged Q-T Interval in a 45-Year-Old Woman

1977; Elsevier BV; Volume: 71; Issue: 2 Linguagem: Inglês

10.1378/chest.71.2.210

1931-3543

Richard R. Schneider, Alan S. Bahler, Joseph B. Pincus, Barry Stimmel,

Receptor Mechanisms and Signaling

The association of congenital deafness, a prolonged Q-T interval, and sudden death was described by Jervell and Lange-Nielson 1 Jervell A Lange-Nielson F Congenital deaf mutism, functional heart disease with prolongation of the Q-T interval and sudden death.. Am Heart J. 1957; 54: 59-68 Abstract Full Text PDF PubMed Scopus (1249) Google Scholar in 1957. The occurrence of an abnormally prolonged Q-T interval, syncope, and sudden death without an associated hearing deficit was subsequently described in 1963. 2 Romano C Gemme G Pongiglione R Aritimie cardiache rare dell'eta pediatrica: 2.. Accessi sincopali per fibrillozione ventricolare parossistics; Presentazione del primo case della letteratura pediatrica italiana. Clin Paediatr (Bologna). 1963; 45: 656-683 Google Scholar , 3 Ward O, Report of the Council of the Royal Academy of Medicine in Ireland. 1963 Google Scholar , 4 Ward O A new familial cardiac syndrome in children.. J Ir Med Assoc. 1964; 54: 103-106 PubMed Google Scholar Since then, approximately 203 cases of idiopathic prolongation of the Q-T interval, accompanied by ventricular arrhythmias and syncope, have been reported. Of these patients, only 73 (36 percent) have had associated deafness. 5 Schwartz PJ Periti M Malliani A The long Q-T syndrome.. Am Heart J. 1975; 89: 378-390 Abstract Full Text PDF PubMed Scopus (736) Google Scholar Although the syndrome is usually present in children and tends to lessen in severity with aging, women as old as 33 6 James T Congenital deafness and cardiac arrhythmias.. Am J Cardiol. 1967; 19: 627-643 Abstract Full Text PDF PubMed Scopus (87) Google Scholar and 36 7 Gamstorp I Nilsen R Westling H Congenital cardiac arrhythmia.. Lancet. 1964; 2: 965 Abstract PubMed Scopus (20) Google Scholar years of age have been described with a prolonged Q-T interval and syncope. The following case report describes a 45-year-old woman who had a five-year documented history of a prolonged Q-T interval unrecognized until the appearance of syncopal episodes and recurrent ventricular tachyarrhythmias necessitated multiple cardiac resuscitative efforts.