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Sexual Habits and Human Papillomavirus Infection Among Females in Three New Independent States of the Former Soviet Union

2003; Lippincott Williams & Wilkins; Volume: 30; Issue: 9 Linguagem: Inglês

10.1097/01.olq.0000079519.04451.d4

1537-4521

Stina Syrjänen, Irena Shabalova, Nicolaj Petrovichev, В. П. Козаченко, Tatjana Zakharova, Julia Pajanidi, J Podistov, G. Yu. Chemeris, Larisa G. Sozaeva, Elena Lipova, Irena Tsidaeva, Olga Ivanchenko, Alla Pshepurko, Sergej Zakharenko, Raisa Nerovjna, Ludmila Kljukina, Oksana Erokhina, Marina Branovskaja, Maritta Ņikitina, Valerija Grujnberga, Alexandr Grujnberg, Anna Juschenko, Bo Johansson, Piero Tosi, Marcella Cintorino, Rosa Santopietro, Karí Syrjänen,

Endometrial and Cervical Cancer Treatments

In Brief Background On a global scale, the New Independent States (NIS) of the former Soviet Union have an intermediate incidence of cervical cancer, the main etiologic factor of which is human papillomavirus (HPV), a major sexually transmitted disease (STD). Recently, the prevalence of all STDs has exploded in these countries. Goal The goal of this study was to examine the sexual habits and HPV prevalence among females in three NIS countries. Study Design In this multinational (European Community-funded) trial, a series of 3,175 consecutive female patients were examined for HPV status (by Hybrid Capture II) at six clinics in Russia, Belarus, and Latvia. A meticulous survey of their sexual habits and other potential risk factors of HPV infections was made by structured questionnaire. Results Three categories of patients were examined: those attending STD clinics (n = 722), gynecological patients (n = 761), and those who participated in cervical cancer screening (n = 1,692). These three categories were significantly differentiated by a large number of key variables, including the HPV detection rate (44.9% of STD patients, 39.8% of gynecological patients, and 24.5% of those who were screened). A wide variety sexual habits of these subjects were predictors of the HPV status in univariate analysis. Binary logistic regression analysis found that six different variables remained as independent predictors of HPV status. Patient category (STD) and (young) age were two highly significant predictors of increased risk (P < 0.0001), whereas having a nonsmoking partner and having zero or one partner during the past 2 years were significant protective factors (P = 0.004 and P = 0.007, respectively). Conclusion The results of this study indicate that women and girls in these NIS countries are conservative in many key characteristics of "high-risk" sexual behavior, such as age at onset of sexual activity, number of partners, and casual sex partners. HPV-positive and HPV-negative groups are clearly distinguished by the same variables identified as the key risk factors of HPV infection and cervical intraepithelial neoplasia in Western countries. This extensive survey of the sexual habits of 3,175 female patients at different risk for cervical intraepithelial neoplasia, human papillomavirus (HPV), and cervical cancer in three New Independent States of the Former Soviet Union showed that highly significant independent predictors (P < 0.0001) of HPV infection in multivariate analysis were patient category and young age, whereas having zero or one partner during the past 2 years and having a nonsmoking partner were protective factors. Females in this cohort were generally conservative in many of the key characteristics of "high-risk" sexual behavior.