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Humoral influences of induced sleep and arousal upon electrical brain activity of animals with crossed circulation

1963; Elsevier BV; Volume: 8; Issue: 3 Linguagem: Inglês

10.1016/0014-4886(63)90036-0

1090-2430

Marcel Monnier, Th. Koller, Stefan Gräber,

Neuroscience and Neural Engineering

Cross circulation experiments were performed on rabbits to determine whether an electrographic sleeplike state induced in the donor by thalamic stimulation, or an electrographic arousal induced by reticular stimulation, influence the recipient brain by extraneuronal humoral mechanisms. We found that stimulation of the mediocentral intralaminary thalamus in the donor induces a significant increase of the delta voltage (computed with an automatic frequency analyzer) after four stimulations (142 ± 20.6%). Synchronously the recipient, crossed with the donor, shows a statistically significant increase of the delta voltage (121 ± 13.3%), usually after the fourth stimulation of the donor. Liminal stimulation of the midbrain reticular system in the donor induces arousal, with significant decrease in delta voltage to 48 ± 13.3% after the first and second stimulation. Parallel to this, the delta voltage decreases significantly in the recipient, to 68 ± 10.6% after the first and second stimulation. These electrographic and statistical results bring new evidence of the possibility that the brain activity of the recipient animal in cross circulation experiments can be influenced humorally by the donor in which experimental sleep or arousal are induced.