Portal de Periódicos da CAPES

New Glucocorticoids. Mechanisms of Immunological Activity at the Cellular Level and in the Clinical Setting a

1990; Wiley; Volume: 595; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1990.tb34310.x

1749-6632

M. Scudeletti, L. Castagnetta, Bruno P. Imbimbo, Francesco Puppo, Ivana Pierri, Francesco Indiveri,

Adrenal Hormones and Disorders

Annals of the New York Academy of SciencesVolume 595, Issue 1 p. 368-382 New Glucocorticoids. Mechanisms of Immunological Activity at the Cellular Level and in the Clinical Settinga M. Scudeletti, Corresponding Author M. Scudeletti Department of Internal Medicine University of Genoa Genoa, ItalyAddress for correspondence: M. Scudeletti, ISMI, Viale Benedetto XV, 6, 16132 Genova, Italy.Search for more papers by this authorL. Castagnetta, L. Castagnetta Hormone Biochemistry Laboratories University of Palermo Palermo, ItalySearch for more papers by this authorB. Imbimbo, B. Imbimbo Research and Development Gruppo Lepetit S.p.A, Como Como, ItalySearch for more papers by this authorF. Puppo, F. Puppo Department of Internal Medicine University of Genoa Genoa, ItalySearch for more papers by this authorI. Pierri, I. Pierri Department of Internal Medicine University of Genoa Genoa, ItalySearch for more papers by this authorF. Indiveri, F. Indiveri Medical Semiotics University of Palermo Palermo, ItalySearch for more papers by this author M. Scudeletti, Corresponding Author M. Scudeletti Department of Internal Medicine University of Genoa Genoa, ItalyAddress for correspondence: M. Scudeletti, ISMI, Viale Benedetto XV, 6, 16132 Genova, Italy.Search for more papers by this authorL. Castagnetta, L. Castagnetta Hormone Biochemistry Laboratories University of Palermo Palermo, ItalySearch for more papers by this authorB. Imbimbo, B. Imbimbo Research and Development Gruppo Lepetit S.p.A, Como Como, ItalySearch for more papers by this authorF. Puppo, F. Puppo Department of Internal Medicine University of Genoa Genoa, ItalySearch for more papers by this authorI. Pierri, I. Pierri Department of Internal Medicine University of Genoa Genoa, ItalySearch for more papers by this authorF. Indiveri, F. Indiveri Medical Semiotics University of Palermo Palermo, ItalySearch for more papers by this author First published: June 1990 https://doi.org/10.1111/j.1749-6632.1990.tb34310.xCitations: 22 a This work was partially supported by a CNR grant n. Progetto Finalizzato Oncologia. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Addison, T. 1855. On the Constitutional and Local Effects of Disease of the Suprarenal Capsules. Samuel Highley. London . 2 Brown-Sequard, C. E. 1856. Recherches experimentales sur la phisiologie et la pathologie des capsule surrénales. C. R. Acad. Sci. 43: 422–425. 3 Tait, J. F., S. A. Simpson & H. M. Grundy. 1952. The effects of adrenal extract on mineral metabolism. Lancet 1: 122–124. 4 Hensch, P. S., E. C. Kendall, C. H. Slocumb & H. F. Polley. 1949. The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydocorticosterone: compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Proc. Staff. Meet. Mayo Clin. 24: 181. 5 Haynes, R. C., Jr. & F. Murad. 1985. Adrenocorticotropic hormone adrenocortical steroids and their synthetic analogs; inhibitors of adrenocortical steroid biosynthesis. In The Pharmacological Basis of Therapeutics, 7th Ed. A. G. Gilman, L. S. Goodman, T. W. Rall & F. Murad, eds. Macmillan Publishing Co. New York . 6 Harrop, G. A., L. J. Soffer, R. Ellsworth & J. H. Trescher. 1933. Studies on the suprarenal cortex. III. Plasma electrolytes and electrolyte excretion during suprarenal insufficiency in the dog. J. Exp. Med. 58: 17–38. 7 Cushing, H. 1932. The basophil adenomas of the pituitary body and their clinical manifestations. Bull. Johns Hopkins Hosp. 50: 137–195. 8 Sayers, G., A. While & C. N. H. Long. 1943. Preparation and properties of pituitary adrenotropic hormone. Biol. Chem. 149: 425–436. 9 Bell, P. H., K. S. Howard, R. G. Shepherd, B. M. Finn & J. H. Meisenhelder. 1956. Studies with corticotropin. II. Pepsin degradation of beta-corticotropin. J. Am. Chem. Soc. 78: 5059–5066. 10 Baxter, J. D. & P. H. Forsham. 1972. Tissue effect of glucocorticoids. Am. J. Med. 53: 573. 11 Fauci, A. S. 1976. Glucocorticosteroid therapy: Mechanisms of action and clinical considerations. Ann. Intern. Med. 84: 304. 12 Baxter, J. D. & G. G. Rousseau. 1979. Glucocorticoid hormone action: An overview. In Glucocorticoid Hormone Action. J. D. Baxter & G. G. Rousseau, Eds. Springer-Verlag. New York . 13 Liddle, G. W. 1960. Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing's syndrome. J. Clin. Endocrinol. Metab. 20: 1539. 14 Andersson, P., P. Edshacker, A. Ryrfeldt & C. Von Bahr. 1982. In vitro biotransformation of glucocorticoids in liver and skin homogenate fractions from man and hairless mouse. J. Steroid Biochem. 16: 787–795. 15 Dahlberg, E., A. Thalen, R. Brattsand et al. 1983. Correlation between chemical structure, receptor binding, and biological activity of some novel, highly active, 16 alpha, 17 alpha-acetal-substituted glucocorticoids. Mol. Pharmacol. 25: 70. 16 Rousseau, G. G. 1984. Control of gene expression by glucocorticoid hormones. Biochem. J. 224: 1. 17 Clark, C. R. 1984. The cellular distribution of steroid hormone receptors: Have we got it right? Trends Biochem. Sci. 9: 207. 18 Bach, J. F. & T. B. Strom. 1985. Corticosteroids. In The Mode of Action of Immunosuppressive Agents. J. L. Turk, Ed. p.: 21. Elsevier. Amsterdam . 19 Baxter, J. D. & J. W. Funder. 1979. Hormone receptors. N. Engl. J. Med. 301: 1149. 20 Svec, F. 1985. Glucocorticoid receptor regulation. Life Sci. 36: 2359–2366. 21 Metzger, W. J., K. Nugent, H. B. Richerson et al. 1985. Methods for bronchoalveolar lavage in asthmatic patients following bronchoprovocation and local antigen challenge. Chest 87(1 suppl.): 16S–9S. 22 Kay, A. B., D. J. Stechschulte & K. F. Austen. 1971. An eosinophil leukocyte chemotactic factor of anaphylaxis. J. Exp. Med. 133: 602. 23 Bochner, B., B. K. Rutledge & R. P. Schleimer. 1987. Interleukin-1 (IL-2) production by human lung tissue. II. Inhibition by antiinflammatory steroids. J. Immunol. 139: 2303–2307. 24 Schliemer, R. P., E. S. Schlman, D. W. MacGlashan et al. 1983. Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells. J. Clin. Invest. 71: 1830–1835. 25 MacGlashan, D. W., Jr., R. P. Schleimer, S. P. Peters et al. 1983. Comparative studies of human basophils and mast cells. Fed. Proc. 42: 2054–2059. 26 Hahn, B. H., R. P. MacDermott, S. B. Jacobs, L. S. Pletscher & M. G. Beale. 1980. Immunosuppressive effects of low doses of glucocorticoids: Effects on autologous and allogeneic MLRs. J. Immunol. 124: 2812–2817. 27 Indiveri, F., M. Scudeletti, D. Viglione, V. Grifoni, C. Russo, N. A. Pellegrino & S. Ferrone. 1981. Modulation of Ia-like antigens on PHA activated human T lymphocytes. In Mechanism of lymphocyte activation. K. Resh & H. Kirkner, eds.: 687–689. Elsevier. Amsterdam . 28 Scudeletti, M., D. Pende, B. Imbimbo, V. Grifoni & F. Indiveri. 1984. Effects of single oral doses of prednisone and deflazacort with human lymphocyte distribution and functions. Analysis with monoclonal antibodies. In Glucocorticoid Effects and Their Biological Consequences. L. V. Avioli, C. Gennari & B. Imbimbo, eds.: 325–344. Plenum Press. New York . 29 Hahn, T. J., L. R. Halstead, B. Strates, B. Imbimbo & D. T. Baran. 1980. Comparison of subacute effects of oxazacort and prednisone on mineral methabolism in man. Calcif. Tissue Int. 31: 109–115. 30 F. Ferrone & C. S. David (eds.) 1982. Ia Antigens. CRC Press. Boca Raton . 31 Snyder, D. S. & E. R. Unanue. 1982. Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production. J. Immunol. 129: 1083. 32 Larsson, E. L. 1980. Cyclosporin A and dexametasone suppress T cell response by selectively acting at distinct sites of the triggering process. J. Immunol. 124: 2828–2833. 33 Smith, K. A., L. B. Lachman, J. J. Oppenheim & M. F. Favata. 1980. The functional relationship of the interleukins. J. Exp. Med. 151: 1551–1556. 34 Neumann, C. & C. Sorg. 1983. Regulation of plasminogen activator secretion, interferon induction, and proliferation in murine macrophages. Eur. J. Immunol. 13: 143–147. 35 Beutler, B. & A. Cerami. 1987. Cachetin: More than a tumor necrosis factor. N. Engl. J. Med. 316: 379–385. 36 Hahn, B. H., R. P. MacDermott, S. B. Jacobs, L. S. Pletscher & M. G. Beale. 1980. Immunosuppressive effects of low doses of glucocorticoids: Effects on autologous and allogeneic mixed leukocyte reactions. J. Immunol. 124: 2812–2817. 37 Cheigh, J. S., K. H. Stezel, R. R. Riggio, E. B. Katz & A. L. Rubin. 1975. Effects of intravenous methylprednisolone on mixed lymphocyte cultures in normal humans. Trans. Proc. 7: 31–35. 38 Fauci, A. S. 1976. Mechanisms of corticosteroid action on lymphocyte subpopulations. II. Differential effects of in vivo hydrocortisone, prednisone and dexamethasone on in vitro expression of lymphocyte function. Clin. Exp. Immunol. 24: 54–62. 39 Novak, E., S. S. Stubbs, C. E. Seckman & M. S. Hearon. 1970. Effects of a single large intravenous dose of methylprednisolone sodium succinate. Clin. Pharmacol. Ther. 11: 711–717. 40 Parrillo, J. E. & A. S. Fauci. 1978. Mechanisms of corticosteroids action on lymphocyte subpopulations. III. Differential effects of dexamethasone administration on subpopulations of effectors cells mediating cellular cytotoxicity in man. Clin. Exp. Immunol. 31: 116–125. 41 Peters, W. P., J. F. Holland, H. Senn, W. Rhomberg & T. Benerjee. 1972. Corticosteroids administration and localized leukocyte mobilization. N. Engl. J. Med. 286: 342–345. 42 Webel, M. L., R. E. Ritts, H. F. Taswell, J. V. Donadio & J. E. Woods. 1974. Cellular immunity after intravenous administration of methylprednisolone. J. Lab. Clin. Med. 83: 383–392. 43 Nathansohn, G. G., G. Winters & E. Testa. 1979. Steroid prossessing nitrogen. III. Synthesis of new highly active corticoids (17alpha, 16alpha-d) oxazoline steroids. J. Med. Chem. 10: 799. 44 Buniva, G., A. Dubini & D. Sassella. 1979. Human bioassay of corticotropin-suppressing eosinopenic and hyperglycaemic potencies of deflazacort and prednisone. Curr. Ther. Res. 26: 69. 45 Canniggia, A., M. Marchetti, C. Gennari et al. 1977. Effects of a new glucocorticoid, oxazacort, on some variables connected with bone metabolism in man: A comparison to prednisone. Int. J. Clin. Pharmacol. Ther. Toxicol 15: 126–134. 46 Gennari, C., B. Imbimbo, M. Montagnani et al. 1984. Effects of short and mediumterm treatments with prednisone and deflazacort on mineral metabolism and parathyroid hormone activity in humans. Calcif. Tissue Int. 36: 245–252. 47 Pagano, G., A. Lombardi, G. M. Feraris, B. Imbimbo & P. Cavallo Perin. 1982. Acute effect of prednisone and deflazacort on glucose tolerance in prediabetic subjects. Eur. J. Clin. Pharmacol. 22: 469–471. 48 Scudeletti, M., C. Piccardo, P. Piovano, B. Imbimbo & F. Indiveri. 1987. Effects of new heterocyclic glucocorticoid, deflazacort (DFC), on rheumatoid arthritis (RA). Int. J. Immunopharmacol. 9: 133–139. 49 Moretta, A., G. Pantaleo, L. Moretta, J. G. Cerottini & M. C. Mingari. 1983. Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity. J. Exp. Med. 157: 743–754. 50 Moretta, A., A. Poggi, D. Olive, C. Bottino, C. Fortis & L. Moretta. 1987. Selection and characterization of T cell variants lacking molecules involved in T cell activation (T3, T cell receptor, T44 and T11). Analysis of the functional relationship among different pathways of activation. Proc. Natl. Acad. Sci. USA 84: 1654–1658. 51 Scudeletti, M., G. Ciprandi, C. Pronzato, G. Passalacqua, B. Imbimbo, M. Bagnasco & G. W. Canonica. 1989. Glucocorticoids and the immune system: Comparison between prednisone, dexamethasone and deflazacort. Int. J. Immunother. 5: 85–90. 52 Brentani, M. M., B. L. Wajchenberg, F. P. Cesar & V. R. Martins. 1986. Regulation of glucocorticoid receptor by glucocorticoids in human mononuclear leukocytes. Hormone Res. 24: 9. 53 Castagnetta, L., M. Lo Casto, T. Mercadante, L. Polito, S. Cowan & R. E. Leake. 1983. Intratumoral variation of oestrogen receptor status in endometrial cancer. Br. J. Cancer 47: 261–267. 54 Castagnetta, L., A. Traina, A. Di Carlo, A. M. Latteri, G. Carruba & R. E. Leake. 1987. Heterogeneity of soluble and nuclear oestrogen receptor status of involved nodes in relation to primary breast cancer. Eur. J. Cancer 5: 421–426. 55 Matsui, M., M. Temponi & S. Ferrone. 1987. Characterization of a monoclonal antibody-defined human melanoma-associated antigen susceptible to induction by immune interferon. J. Immunol. 139: 2088–2095. 56 Carrel, S., A. Schmidt-Kessen & L. Giuffre'. 1985. Recombinant gammainterferon can induce the expression of HLA-DR and -DC on DR-negative melanoma cells and enhance the expression of HLA-ABC and tumor associated antigens. Eur. J. Immunol. 15: 118–123. 57 Anichini, A., C. Castelli, G. Sozzi, G. Fossati & G. Parmiani. 1988. Differential susceptibility to recombinant interferon-gamma-induced HLA-DQ antigen modulation among clones from a human metastatic melanoma. J. Immunol. 140: 183–191. Citing Literature Volume595, Issue1Steroid Formation, Degradation, and Action in Peripheral TissuesJune 1990Pages 368-382 ReferencesRelatedInformation