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Anaphylactoid Reaction to Muromonab‐CD3 in a Pediatric Renal Transplant Recipient

2000; Wiley; Volume: 20; Issue: 1 Linguagem: Inglês

10.1592/phco.20.1.100.34666

1875-9114

Robert J. Berkowitz, Carl J. Possidente, Bruce R. McPherson, Ann Guillot, Stuart V. Braun, Jeffrey Reese,

Mast cells and histamine

Muromonab‐CD3 (OKT3), a murine IgG2a antibody directed against the T3 (CD3) complex on mature lymphocytes, triggers adverse immune reactions. Anaphylactic reactions have occurred in patients exposed to OKT3 and are mediated by anti‐OKT3 IgE antibodies. The reactions are not antibody mediated and can occur within seconds of administration of a mast cell secretogogue. A renal transplant recipient became hypotensive and hypoxic immediately after receiving her first dose of OKT3 and required advanced life support. Serum antibody tests were negative for anti‐OKT3 IgG, IgE, and antimouse protein antibodies. To our knowledge, this is the first published report of a patient with an anaphylactoid reaction to the initial infusion of OKT3.