NaIO 4 /LiBr-mediated Diastereoselective Dihydroxylation of Olefins: A Catalytic Approach to the Prevost−Woodward Reaction
2005; American Chemical Society; Volume: 7; Issue: 22 Linguagem: Inglês
10.1021/ol052080n
ISSN1523-7060
AutoresLourdusamy Emmanuvel, Tanveer Mahamadali Shaikh, Arumugam Sudalai,
Tópico(s)Synthesis and Catalytic Reactions
Resumo[reaction: see text] LiBr catalyzes efficiently the dihydroxylation of alkenes to afford syn and anti diols with excellent diastereoselectivity depending upon the use of NaIO(4) (30 mol %) or PhI(OAc)(2) (1 equiv), respectively, as the oxidants. The oxidation of non-benzylic halides has been achieved for the first time to afford the corresponding diols in excellent yields.
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