Synthesis of New 5-Substituted Hydantoins and Symmetrical Twin-Drug Type Hydantoin Derivatives
2014; Pharmaceutical Society of Japan; Volume: 62; Issue: 5 Linguagem: Inglês
10.1248/cpb.c14-00017
ISSN1347-5223
AutoresFumiko Fujisaki, Hatsumi Aki, Ayumi Naito, Enko Fukami, Nobuhiro Kashige, Fumio Miake, Kunihiro Sumoto,
Tópico(s)Fluorine in Organic Chemistry
ResumoIn connection with our studies on hydantoin derivatives, a conventional regioselective chemical transformation of 5-methylene hydantoins 4a–c to 5-aminomethyl-substituted hydantoins 5–10 or to 5-amino-5-methyl-disubstituted hydantoins 11–14 is described. Synthesis of bivalent twin-drug type hydantoin derivatives 19–24 and the binding property of a bivalent symmetrical hydantoin derivative 24b to sulfated glycosaminoglycans are also described.
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