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Optimizing approaches to head and neck cancer: strengths and weaknesses in multidisciplinary treatments of locally advanced disease

2008; Elsevier BV; Volume: 19; Linguagem: Inglês

10.1093/annonc/mdn447

1569-8041

J. Giralt, Sergi Benavente, M. Arguís,

Salivary Gland Tumors Diagnosis and Treatment

Head and neck cancer (HN nasal cavity and paranasal sinuses; oropharynx; oral cavity; larynx; hypopharynx; salivary glands; and thyroid glands. Most of these sites have several subsites. Their anatomic situation means that treatment can affect vital functions, such as speech or swallowing, that may considerately reduce a patient’s quality of life. Squamous cell carcinoma (SCC) is the most frequent histological type; other tumours are classified as carcinomas (undifferentiated, anaplastic epithelial), adenocarcinomas (adenoid cystic, mucoepidermoid, salivary duct), estesioneuroblastoma or lymphomas. Such anatomic and pathological variability affects diagnosis, tumour biology, prognosis and treatment [3]. Given this complexity, it is not surprising that clinical management is also complicated and requires a concerted effort among multiple specialties.