Elevation of serum lipids after chronic administration of amiodarone in rabbits
1982; Elsevier BV; Volume: 44; Issue: 1 Linguagem: Inglês
10.1016/0021-9150(82)90049-1
ISSN1879-1484
AutoresRamaswamy Kannan, Arnold Pollak, Bramah N. Singh,
Tópico(s)Adipose Tissue and Metabolism
ResumoAmiodarone hydrochloride is a potent, iodine-containing antiarrhythmic compound with a long elimination half-life, whose cardiac action appears to be mediated through an interference with thyroxine-dependent pathways in the heart. Whether it has any effect on lipid metabolism is not known. Its effect (20 mg/kg per day intraperitoneally) after 3 and 6 weeks of treatment on changes in serum lipoproteins were studied in male New Zealand white rabbits. Serum amiodarone levels reached a steady state (∼ 0.50 μg/ml) after 3 weeks, and serum reverse T3 (an index of drug dose and duration of treatment) increased 3–4 fold by 3 and 6 weeks. In two discrete sets of studies, serum triglyceride (TG) and total cholesterol (CHOL) increased significantly (P < 0.01) after 3 and 6 weeks on amiodarone when compared to the values in a control series of animals. Phospholipid (PL) levels were not changed. Very low density lipoproteins (VLDL) in the drug-treated groups showed a significant increase in triglyceride (P < 0.01) and in apoprotein B (P < 0.05). There was no change in low density lipoprotein (LDL)-total cholesterol levels, but there was a significant increase in low density lipoprotein-apoprotein B levels. Whether the abnormalities observed in serum lipids induced by amiodarone are mediated through changes in thyroid hormones or occur as a result of a direct effect on lipid metabolism is unknown, but the problem merits further investigation.
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