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c-myc oncogene expression and clinical outcome in carcinoma of the cervix

1989; Elsevier BV; Volume: 3; Issue: 2 Linguagem: Inglês

10.1016/0890-8508(89)90022-4

1096-1194

Anuradha Sowani, Gloria Ong, Stanley Dische, Cecily Quinn, J.O. White, Pat Soutter, Jonathan Waxman, Karol Sikora,

Virus-based gene therapy research

The expression of the c-myc oncogene was studied in paraffin-embedded specimens of cervical biopsies using a monoclonal antibody which binds to the 62,000 Dalton protein encoded by the c-myc gene. A range of cervical cancers from intraepithelial neoplasia to advanced grade IV tumours were studied together with normal cervical biopsies; c-myc status was correlated to clinical progress. There was no correlation seen between the clinical stage of the disease at presentation and c-myc expression. The 15 patients with c-myc negative cervical cancers were shown to have better disease free (mean--95.4 mos) and total survival (mean 118.0--mos) compared to the 16 patients that were c-myc positive 28.4 and 48.4 mos respectively). The pattern of recurrence differed between the two groups with c-myc positive tumours more likely to develop extra pelvic metastatic disease. The c-myc status of cervical cancer offers a prognostic indicator that could be useful in guiding treatment decisions.