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CTX-M-1 Extended-Spectrum β-Lactamase-Producing Proteus mirabilis in Greece

2005; Mary Ann Liebert, Inc.; Volume: 11; Issue: 4 Linguagem: Inglês

10.1089/mdr.2005.11.351

1931-8448

Paraskevi Karapavlidou, Danai Sofianou, Evangelos Manolis, Spyros Pournaras, Athanassios Tsakris,

Antimicrobial Resistance in Staphylococcus

To examine the dissemination of CTX-M-type extended-spectrum beta-lactamases (ESBLs) in clinical isolates of Proteus mirabilis, 91 nonrepetitive ESBL-producing P. mirabilis were collected from infected patients in a tertiary Greek hospital during September, 2001, to May, 2004. A bla (CTX-M) gene was amplified in one isolate (strain A328), but bla (CTX-M) was not detected in any of the remaining ESBL producers. Sequencing results showed that P. mirabilis A328 produced a CTX-M-1 enzyme while PCR mapping of the genetic element carrying bla (CTX-M-1) revealed that the gene was located downstream of an ISEcp1B element. The cefotaxime resistance determinant was easily transferable and carried on a 70-kb plasmid. The emergence of CTX-M-1- producing P. mirabilis indicates the need for early recognition of such strains to be able to control their spread in our hospital and community environment.