Cross Interaction Between Auxiliaries: The Chirality of Amino Alcohols by NMR
2008; American Chemical Society; Volume: 10; Issue: 13 Linguagem: Inglês
10.1021/ol8008528
ISSN1523-7060
AutoresVictoria Leiro, José Manuel Seco, Emilio Quiñoá, Ricardo Riguera,
Tópico(s)Analytical Chemistry and Chromatography
ResumoThe absolute configuration of sec/prim- and prim/sec-1,2-amino alcohols is determined by comparison of the 1H NMR chemical shifts of the auxiliary OMe or CαH groups at the corresponding bis-(R) and bis-(S)-MPA derivatives. This is the first NMR method that allows the assignment of absolute configuration without resorting to the shifts of hydrogens at the substrate and is based on the cross anisotropic interactions between auxiliaries.
Referência(s)