A new ligation method for N-terminal tryptophan-containing peptides using the Pictet–Spengler reaction
2000; Elsevier BV; Volume: 41; Issue: 21 Linguagem: Inglês
10.1016/s0040-4039(00)00592-x
ISSN1873-3581
AutoresXianfeng Li, Lianshan Zhang, Steven E. Hall, James P. Tam,
Tópico(s)Chemical Synthesis and Reactions
ResumoApplication of a carbon–carbon bond forming reaction for ligating unprotected peptides in acetic acid is described based on a Pictet–Spengler condensation. The peptide segments include a peptide with a Trp at the N-terminal and another with a C-terminal aldehyde, which can be generated through a new cyclic acetal resin.
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