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The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome

2014; Informa; Volume: 31; Issue: 3 Linguagem: Inglês

10.3109/09513590.2014.976546

1473-0766

Ana Santos, Nayara Pereira Soares, Eduardo Caldas Costa, Joceline Cássia Ferrezini de Sá, George Dantas Azevedo, Telma Maria Araújo Moura Lemos,

Lipid metabolism and disorders

To evaluate inflammatory markers and insulin resistance (IR) in women with and without polycystic ovary syndrome (PCOS), with different body mass index (BMI).Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) were assessed in serum samples from 40 women in reproductive age. Patients were divided into four groups: I (non-eutrophic with PCOS, n = 12), II (non-eutrophic without PCOS, n = 10), III (eutrophic with PCOS, n = 8) and IV (eutrophic without PCOS, n = 10) being non-eutrophic, the overweight and obese women with BMI > 25 kg/m2 and eutrophic women with BMI < 24.9 kg/m2. Homeostatic model assessment (HOMA-IR) was calculated for evaluation of IR.PCOS patients showed increased levels of CRP (p < 0.01) and HOMA-IR (p < 0.01). When divided by BMI, both non-eutrophicad eutrophic PCOS showed increased CRP levels (p < 0.01) and HOMA-IR (p < 0.01). There were no differences in TNF-α and IL-6 levels between groups.In the PCOS group, the levels of CRP and IR were elevated, compared to their counterparts, regardless of body mass.