Revisão Acesso aberto Revisado por pares

Erythropoietin: Physiologic Basis for Clinical Applications

1993; Wiley; Volume: 65; Issue: 3 Linguagem: Inglês

10.1111/j.1423-0410.1993.tb02143.x

ISSN

1423-0410

Autores

Stephen J. Schuster, J. Jaime,

Tópico(s)

Iron Metabolism and Disorders

Resumo

Vox SanguinisVolume 65, Issue 3 p. 169-179 Free Access Erythropoietin: Physiologic Basis for Clinical Applications Stephen J. Schuster, Corresponding Author Stephen J. Schuster Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pa., USACardeza Foundation for Hematologic Research Department of Medicine, Thomas Jefferson University 1015 Walnut Street Philadelphia, PA 19107-5099 (USA)Search for more papers by this authorJaime Caro, Jaime Caro Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pa., USASearch for more papers by this author Stephen J. Schuster, Corresponding Author Stephen J. Schuster Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pa., USACardeza Foundation for Hematologic Research Department of Medicine, Thomas Jefferson University 1015 Walnut Street Philadelphia, PA 19107-5099 (USA)Search for more papers by this authorJaime Caro, Jaime Caro Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pa., USASearch for more papers by this author First published: October 1993 https://doi.org/10.1111/j.1423-0410.1993.tb02143.xCitations: 11AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Erslev AJ Blood and mountains; in MM Wintrobe (ed): Blood, Pure and Eloquent. New York. McGraw-Hill, 1980, p 257. 2 Jourdanet D De l'anémie des altitudes et de l'anémie en général dans ses rapports avec la pression de I'atmosphère. Paris, Bailliére, 1863. 3 Viault P Sur l'augmentation considérable du nombre des globules rangés dans le sang chez les habitants des hauts plateaux de l'amérique du sud. CR Acad Sci (Paris) 1890; 119: 917. 4 Hurtado A, Merino C, Delgado E Influence of anoxemia on the hemopoietic activity. Arch Intern Med 1945; 75: 284. 5 Miescher F Über die Beziehungen zwischen Meereshöhe und Beschaffenheit des Blutes. Correspondenzbl Schweiz Arzte. 1893; 24: 809. 6 Carnot P, Deflandre C Sur l'activité hémo-poiétique du sérum au cours de la régénération du sang. CR Acad Sci (Paris) 1906; 143: 432. 7 Reissmann KR Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia. Blood 1950; 5: 372. 8 Erslev AJ Humoral regulation of red cell production. Blood 1953; 8: 349. 9 Hodgson G, Toha J The erythropoietin effect of urine and plasma of repeatedly bled rabbits. Blood 1954; 9: 299. 10 Miyake T, Kung CKH, Goldwasser E Purification of human erythropoietin. J Biol Chem 1977; 252: 5558. 11 Jacobs K, Shoemaker C, Rudersdorf R, Neill SD, Kaufman RJ, Mufson A, Seehra J, Jones SS, Hewick R, Fritsh EF, Kawakita M, Shimizu T, Miyake T Isolation and characterization of genomic and cDNA clones of human EPO. Nature 1985; 313: 806. 12 Lin F-K, Suggs S, Lin C-H, Browne JK, Smalling R, Egrie JC, Chen KK, Fox GM, Martin F, Stabinsky Z, Badrawi SM, Lai PH, Goldwasser E Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci USA 1985; 82: 7580. 13 Erslev AJ, Wilson J, Caro J Erythropoietin titers in anemic, nonuremic patients. J Lab Clin Med 1987; 109: 429. 14 Erslev AJ, Caro J, Kansu E, Miller OP, Cobbs E Plasma erythropoietin in polycythemia. Am J Med 1979; 66: 243. 15 Jacobson LO, Goldwasser E, Plzak L, Fried W Studies on erythropoiesis. IV. Reticulocyte response of hypophysectomized and polycythemic rodents to erythropoietin. Proc Soc Exp Biol Med 1957; 94: 243. 16 Adamson JW, Finch CA Hemoglobin function, oxygen affinity, and erythropoietin. Annu Rev Physiol 1975; 37: 151. 17 Jacobson LO, Goldwasser E, Fried W, Plzak L Role of the kidney in erythropoiesis. Nature 1957; 179: 633. 18 Jacobson LO, Marks EK, Gaston EO, Goldwasser E Studies on erythropoiesis. XI. Reticulocyte response of transfusion-induced polycythemic mice to anemic plasma from nephectomized mice and to plasma from nephrectomized rats exposed to low oxygen. Blood 1959; 14: 635. 19 Naets JP Erythropoiesis in nephrectomized dogs. Nature 1958; 181: 1134. 20 Naets JP, Wittek M Erythropoiesis in anephric man. Lancet 1968; 1: 941. 21 Caro J, Brown S, Miller OP, Murray T, Erslev AJ Erythropoietin levels in uremic nephric and anephric patients. J Lab Clin Med 1979; 93: 449. 22 Radtke HW, Erbes PM, Schippers E, Koch KM Serum erythropoietin concentration in anephric patients. Nephron 1978; 22: 361. 23 McGonigle RJS, Wallin JD, Shadduck RK, Fisher JW Erythropoietin deficiency and inhibition of erythropoiesis in renal insufficiency. Kidney Int 1984; 25: 437. 24 Fried W, Plzak L, Jacobson LO, Goldwasser E Studies on erythropoiesis. III. Factors controlling erythropoietin production. Proc Soc Exp Biol Med 1957; 94: 237. 25 Schuster SJ, Wilson JH, Erslev AJ, Caro J Physiologic regulation and tissue localization of renal erythropoietin messenger RNA. Blood 1987; 70: 316. 26 Bondurant MC, Koury MJ Anemia induces accumulation of erythropoietin mRNA in the kidney and liver. Mol Cell Biol 1986; 6: 2731. 27 Beru W, McDonald J, Lacombe C, Goldwasser E Expression of the mouse erythropoietin gene. Mol Cell Biol 1986; 6: 2571. 28 Schuster SJ, Badiavas EV, Costa-Giomi P, Weinmann R, Erslev AJ, Caro J Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure. Blood 1989; 73: 13. 29 Goldberg MA, Gaut CC, Bunn HF Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Blood 1991; 77: 271. 30 Beck I, Ramirez S., Weinmann R, Caro J Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. J Biol Chem 1991; 266: 15563. 31 Pugh CW, Tan CC, Jones RW, Ratcliffe PJ Functional analysis of an oxygen-regulated transcriptional enhancer lying 3′ to the mouse erythropoietin gene. Proc Natl Acad Sci USA 1991; 88: 10553. 32 Semenza GL, Koury ST, Nejfelt MK, Gear-hart JD, Antonarakis SE Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc Natl Acad Sci USA 1991; 88: 8725. 33 Semenza GL, Dureza RC, Traystman MD, Gearhart JD, Antonarakis SE Human erythropoietin gene expression in transgenic mice: Multiple transcription initiation sites and cisacting regulatory elements. Mol Cell Biol 1990; 10: 930. 34 Costa-Giomi P, Caro J, Weinmann R Enhancement by hypoxia of human erythropoietin gene transcription in vitro. J Biol Chem 1990; 265: 10185. 35 Fisher JW, Langston, JW The influence of hypoxemia and cobalt on erythropoietin production in the isolated perfused dog kidney. Blood 1967; 29: 114. 36 Zangheri EO, Campana H, Ponce F, Silva JC, Fernandez FO, Suarez JR Production of erythropoietin by anoxic perfusion of the isolated kidney of a dog. Nature 1963; 199: 572. 37 Ratcliffe PJ, Jones RW, Phillips RE, Nieholls LG, Bell JI Oxygen-dependent modulation of erythropoietin mRNA levels in isolated rat kidneys studied by RNase protection. J Exp Med 1990; 172: 657. 38 Koury ST, Bondurant MC., Koury MJ Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood 1988; 71: 524. 39 Lacombe C, DaSilva JL, Bruneval P, Fournier JG, Wendling F, Casadevall N, Camilleri JP, Bariety J, Varet B, Tambourin P Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney. J Clin Invest 1988; 81: 620. 40 Maxwell AP, Lappin TR, Johnston CF, Bridges JM, McGeown MC Erythropoietin production in kidney tubular cells. Br J Haematol 1990; 74: 535. 41 Schuster SJ, Koury ST, Bohrer M, Salceda S, Caro J Cellular sites of extrarenal and renal erythropoietin production in anaemic rats. Br J Haematol 1992; 81: 153. 42 Goldberg MA, Dunning SP, Bunn HF Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein. Science 1988; 242: 1412. 43 Erslev AJ, Caro J, Kansu E, Silver R Renal and extrarenal erythropoietin production in anemic rats. Br J Haematol 1980; 45: 65. 44 Fried W The liver as a source of extrarenal erythropoietin production. Blood 1972; 40: 671. 45 Zanjani ED, Poster J, Burlington H, Mann LI, Wasserman LR Liver as the primary site of erythropoietin formation in the fetus. J Lab Clin Med 1977; 89: 640. 46 Zanjani ED, Ascensao JL, McGlave PB; Banisadre M, Ash RC Studies on the liver to kidney switch of erythropoietin production. J Clin Invest 1981; 67: 1183. 47 Gruber DF, Zucali JR, Wleklinski J, LaRussa V, Mirand EA Temporal transition in the site of rat erythropoietin production. Exp Haematol 1977; 5: 399. 48 Peschle C, Marone G, Genovese A, Cillo C, Magli C, Condorelli M Erythropoietin production by the liver in fetal-neonatal life. Life Sci 1975; 17: 1325. 49 Koury ST, Bondurant MC, Koury MJ, Semenza GL Localization of cells producing erythropoietin in murine liver by in situ hybridization. Blood 1991; 77: 2497. 50 Erslev AJ, KcKenna PJ, Capelli JP, Hamburger RJ, Cohn HE, Clark JE Rate of red cell production in two nephrectomized patients. Arch Intern Med 1968; 122: 230. 51 Espada J, Brandan NC, Dorado M Effect of chemical and enzymatic agents on the biological activity of erythropoietin. Acta Physiol Latinoam 1973; 23: 193. 52 Erslev AJ Erythropoietin assay; in WJ Williams, E Beutler, AJ Erslev, MA Lichtman (eds): Hematology. New York, McGraw-Hill, 1983, p 1634. 53 Annable L, Cotes PM, Mussett MV The second international reference preparation of erythropoietin, human urinary, for bioassay. Bull WHO 1972; 47: 99. 54 Dunn CDR, Jarvis JH, Greenman JM A quantitative bioassay for erythropoietin using mouse fetal liver cells. Exp Hematol 1975; 3: 65. 35 Haga P, Falkanger S In vitro assay for erythropoietin: Erythroid colony formation in methyl cellulose used for the measurement of erythropoietin in plasma. Blood 1979; 53: 1172. 56 Goldwasser E, Sherwood JB Radioimmunoassay of erythropoietin. Br J Haematol 1981; 48: 359. 57 Garcia JF, Ebbe SN, Hollander L, Cutting HO, Miller ME, Cronkite EP Radioimmunoassay of erythropoietin: Circulating levels in normal and polycythemic human beings. J Lab Clin Med 1982; 99: 624. 58 Cotes PM, Das REG, Tam RC The use of 125I recombinant DNA derived human erythropoietin (R-HuEPO) as a replacement for 125I human urinary EPO as tracer antigen in a radioimmunoassay for human EPO; in IN Rich (ed): Molecular and Cellular Aspects of Erythropoietin and Erythropoiesis, NATO ASI Series H: Cell Biology, Berlin, Springer-Verlag, 1987, vol 8, p. 389. 59 Cotes PM, Tam RC, Reed P, Hellebostad M An immunological cross-reactant of erythropoietin in serum which may invalidate EPO radioimmunoassay. Br J Haematol 1989; 73: 265. 60 Sherwood JB, Carmichael LD, Goldwasser E The heterogeneity of circulating human serum erythropoietin. Endocrinology 1988; 122: 1472. 61 Davis JM, Arakawa T, Strickland TW, Yphantis DA Characterization of recombinant human erythropoietin produced in Chinese hamster ovary cells. Biochemistry 1987; 26: 2633. 62 Browne JK, Cohen AM, Egrie JC, Lai PH, Lin FK, Strickland T, Watson E, Stebbing N Erythropoietin gene cloning, protein structure, and biological properties. Cold Spring Harb Symp Quant Biol 1986; 51: 693. 63 Recny MA, Scoble HA, Kim Y Structural characterization of natural human urinary and recombinant DNA-derived erythropoietin. J Biol Chem 1987; 262: 17156. 64 Goldwasser E The structure-function relationship of erythropoietin; in AJ Erslev, JW Adamson, JW Eschbach, CG Winearls (eds): Erythropoietin: Molecular, Cellular and Clinical Biology. Baltimore, The Johns Hopkins University Press, 1991, p. 41. 65 Wang FF, Kung CKH, Goldwasser E Some chemical properties of human erythropoietin. Endocrinology 1985; 116: 2286. 66 Jelkmann W Erythropoietin: Structure, control of production, and function. Physiol Rev 1992; 72: 449. 67 Dordal MS, Wang FF, Goldwasser E The role of carbohydrate in erythropoietin action. Endocrinology 1985; 116: 2293. 68 Nielson OJ, Schuster SJ, Kaufman R, Erslev AJ, Caro J Regulation of erythropoietin production in a human hepatoblastoma cell line. Blood 1987; 70: 1904. 69 Dube S, Fisher JW, Powell JS Glycosylation at specific sites of erythropoietin is essential for biosynthesis, secretion and biological function. J Biol Chem 1988; 263: 17516. 70 Spivak JL, Hogans BB The in vivo metabolism of recombinant human erythropoietin in the rat. Blood 1989; 73: 90. 71 Goldwasser E, Kung CKH, Eliason J On the mechanism of erythropoietin-induced differentiation. XIII. The role of sialic acid on erythropoietin action. J Biol Chem 1974; 249: 4202. 72 Sasaki H, Bothner B, Dell A, Fukuda M Carbohydrate structure of erythropoietin expressed in Chinese hamster ovary cells by a human erythropoietin cDNA. J Biol Chem 1987; 262: 12059. 73 Powell JS, Berkner KL, Lebo RV, Adamson JW Human erythropoietin gene: High level expression in stably transfected mammalian cells and chromosome localization. Proc Natl Acad Sci USA 1986; 83: 6465. 74 Shoemaker C, Mitsock LD Murine erythropoietin gene: Cloning, expression and human gene homology. Mol Cell Biol 1986; 6: 849. 75 McDonald JD, Lin F-K, Goldwasser E Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene. Mol Cell Biol 1986; 6: 842. 76 Lin FK, Lin CH, Lai PH, Browne JK, Egrie JC, Smalling R, Fox GM, Chen KK, Castro M, Suggs S Monkey erythropoietin gene: Cloning, expression, and comparison with the human erythropoietin gene. Gene 1986; 44: 201. 77 Embury SH, Garcia JF, Mohandas N, Pen-nathurdas R, Clark R Effects of oxygen inhalation on endogenous erythropoietin kinetics, erythropoiesis, and properties of blood cells in sickle cell anemia. N Engl J Med 1984; 311: 291. 78 Eckardt KU, Boutellier U, Kurtz A, Schopen M, Koller EA, Bauer C Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia. J Appl Physiol 1989; 66: 1785. 79 Macdougall IC, Roberts DE, Coles GA, Williams JD Clinical pharmacokinetics of epoetin (recombinant human erythropoietin). Clin Pharmacokinet 1991; 20: 99. 80 Flaharty KK, Caro J, Erslev A., Whalen JJ, Morris EM, Bjornsson TD., Vlasses PH Pharmacokinetics and erythropoietic response to human recombinant erythropoietin in healthy men. Clin Pharmacol Ther 1990; 47: 557. 81 Sawyer ST, Krantz SB, Goldwasser E Binding and receptor-mediated endocytosis of erythropoietin in Friend virus-infected erythroid cells. J Biol Chem 1987; 262: 5554. 82 Naets JP, Wittek M Effect of erythroid hyperplasia on the disappearance rate of erythropoietin on the dog. Acta Haematol 1968; 39: 42. 83 Piroso E, Flaharty KK, Caro J, Erslev AJ Erythropoietin half-life in rats with hypoplastic and hyperplastic bone marrows (abstract). Blood 1989; 74: 270a. 84 Rosse WF, Waldmann TA The metabolism of erythropoietin in patients with anemia due to deficient erythropoiesis. J Clin Invest 1964; 43: 1348. 85 Kindler J, Eckardt KU, Ehmer B, Jandeleit K, Kurtz A Single-dose pharmacokinetics of recombinant human erythropoietin in patients with various degrees of renal failure. Nephrol Dial Transplant 1989; 4: 345. 86 Till JE, McCulloch EA, Siminovitch L A stochastic model of stem cell proliferation, based on the growth of spleen colony forming cells. Proc Natl Acad Sci USA 1964; 51: 29. 87 Nakahata T, Gross AJ, Ogawa M A stochastic model of self-renewal and commitment to differentiation of the primitive hemopoietic stem cells in culture. J Cell Physiol 1982; 113: 455. 88 Spivak JL The mechanism of action of erythropoietin. Int J Cell Cloning 1986; 4: 139. 89 Axelrad AA, McLeod DL, Shreeve MM, Health DJ Properties of cells that produce erythrocytic colonies in vitro: in WA Robinson (ed): Proceedings of the Second International Workshop on Hemopoiesis in Culture. Washington, US Government Printing Office, 1974. 90 Iscove NN, Sieber F Erythroid progenitors in mouse bone marrow detected by macroscopic colony formation in culture. Exp Hematol 1975; 3: 32. 91 Gregory CJ Erythropoietin sensitivity as a differentiation marker in the hemopoietic system: Studies of three erythropoietic colony responses in culture. J Cell Physiol 1976; 89: 289. 92 Iscove NN The role of erythropoietin in regulation of population size and cell cycling of early and late erythroid precursors in mouse bone marrow. Cell Tissue Kinet 1977; 10: 323. 93 Udupa KB, Riessman KR In vivo erythropoietin requirements of regenerating erythroid progenitors (BFU-E, CFU-E) in bone marrow of mice. Blood 1979; 53: 1164. 94 Adamson JW, Torok-Storb B, Lin N Analysis of erythropoiesis by erythroid colony formation in culture. Blood Cells 1978; 4: 89. 95 Iscove NN Erythropoietin-independent stimulation of early erythropoiesis in adult marrow cultures by conditioned media from lectin stimulated mouse spleen cells; in DW Golde, MJ Cline, D Metcalf (eds): Hemopoietic Cell Differentiation. ICN-UCLA Symposia on Molecular and Cellular Biology. New York, Academic Press, 1978, vol 10, p. 35. 96 Goodman JW, Hall EA, Miller KL, Shinpock SG Interleukin 3 promotes erythroid burst formation in 'serum free' cultures without detectable erythropoietin. Proc Natl Acad Sci USA 1985; 82: 329. 97 Dai CH, Krantz SB, Zsebo KM Human burst-forming units-erythroid need direct interaction with stem cell factor for further development. Blood 1991; 78: 2493. 98 Sawada K, Krantz SB, Dessypris EN, Koury ST, Sawyer ST Human colony-forming units-erythroid do not require accessory cells, but do require direct interaction with insulin-like growth factor I and/or insulin for erythroid development. J Clin Invest 1989; 83: 1701. 99 Krantz SB, Sawada KI Growth of highly purified human CFU-E in serum-free medium. Prog Clin Biol Res 1990; 352: 9. 100 Dessypris EN, Krantz SB Effect of pure erythropoietin on DNA synthesis by human marrow day 15 erythroid burst forming units in short-term liquid culture. Br J Haematol 1984; 56: 295. 101 Koury MJ, Bondurant MC Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. Science 1990; 248: 378. 102 Spivak JL, Pham T, Isaacs M, Hankins WD Erythropoietin is both a mitogen and a survival factor. Blood 1991; 77: 1228. 103 Krantz SB, Goldwasser E Specific binding of erythropoietin to spleen cells infected with the anemia strain of Friend virus. Proc Natl Acad Sci USA 1984; 81: 7574. 104 Sawada K, Krantz SB, Kans JS, Dessypris EN, Sawyer S, Glick AD, Clivin CI Purification of human erythroid colony forming units and demonstration of specific binding of erythropoietin. J Clin Invest 1987; 80: 357. 105 Sawada K, Krantz SB, Sawyer ST, Civin CI Quantitation of specific binding of erythropoietin to human erythroid colony-forming cells. J Cell Physiol 1988; 137: 337. 106 Broudy VC, Lin N, Brice M, Nakamoto B, Papayannopoulo T Erythropoietin receptor characteristics on primary human erythroid cells. Blood 1991; 77: 2583. 107 Sawada K, Krantz SB, Dai CH, Koury ST, Horn ST, Glick AD, Clivin CI Purification of human blood burst-forming units erythroid and demonstration of the evolution of erythropoietin receptors. J Cell Physiol 1990; 142: 219. 108 Sawyer ST, Krantz SB, Luna J Identification of the receptor for erythropoietin by cross-linking to Friend virus-infected erythroid cells. Proc Natl Acad Sci USA 1987; 84: 3690. 109 Hosoi T, Sawyer ST, Krantz SB Photoaffinity labeling of the erythropoietin receptor and its identification in a ligand-free form. Biochemistry 1991; 30: 329. 110 Sawyer ST The two proteins of the erythropoietin receptor are structurally similar. J Biol Chem 1989; 264: 13343. 111 D'Andrea AD, Lodish HF, Wong GG Expression cloning of the murine erythropoietin receptor. Cell 1989; 57: 277. 112 Winkelman JC, Penny LA, Deavan LL, Forget BG, Jenkins RB The gene for the human erythropoietin receptor: Analysis of the coding sequence and assignment to chromosome 19p. Blood 1990; 76: 24. 113 Jones SS, D'Andrea AD, Haines LL, Wong GG Human erythropoietin receptor: Cloning expression and biological characterization. Blood 1990; 76: 31. 114 Wong GG, Jones SS, D'Andrea AD The molecular biology of erythropoietin receptors; in AJ Erslev, JW Adamson; JW Eschbach, CG Winearls (eds): Erythropoietin: Molecular, Cellular and Clinical Biology. Baltimore, The Johns Hopkins University Press, 1991, p. 133. 115 Atkins HL, Broudy VC, Papayannopoulo T Characterization of the structure of the erythropoietin receptor by ligand blotting. Blood 1991; 77: 2577. 116 Winearls CG, Oliver DO, Pippard MJ, Reid C, Downing MR, Cotes PM Effect of human erythropoietin derived from recombinant DNA on the anaemia of patients maintained by chronic haemodialysis. Lancet 1986; 2: 1175. 117 Eschbach JW, Egrie JC, Downing MR, Browne JK, Adamson JW Correction of the anemia of end-stage renal disease with recombinant human erythropoietin. N Engl J Med 1987; 316: 73. 118 AJ Erslev, JW Adamson, JW Eschbach, CG Winearls (eds): Erythropoietin: Molecular, Cellular and Clinical Biology. Baltimore, The Johns Hopkins University Press. 1991. 119 Eschbach JW, Abdulhadi MH, Browne JK, Delano BG, Downing MR, Egrie JC, Evans RW, Friedman EA, Graber SE, Haley NR, Korbet S, Krantz SB, Lundin AP, Nissenson AR, Ogden DA, Paganini EP, Rader B, Rutsky EA, Stivelman J, Stone WJ, Teschan P, Van Stone JC, Van Wyck DB., Zuckerman K, Adamson JW Recombinant human erythropoietin in anemic patients with end-stage renal disease: Results of a phase III multicenter clinical trial. Ann Intern Med 1989; 111: 992. 120 Ad Hoc Committee for the National Kidney Foundation: Statement on the clinical use of recombinant erythropoietin in anemia of end-stage renal disease. Am J Kidney Dis 1989; 14: 163. 121 Eschbach JW, Adamson JW Guidelines for recombinant human erythropoietin therapy. Am J Kidney Dis 1989; 14 (suppl 1): 2. 122 Zappacosta AR, Perras ST, Bell A Weekly subcutaneous recombinant human erythropoietin corrects anemia of progressive renal failure. Am J Med 1991; 91: 229. 123 Lim VS, DeGowin RL, Zavala D, Kirchner PT, Abels R, Perry P, Fangman J Recombinant human erythropoietin treatment in predialysis patients: A double-blind placebo-controlled trial. Ann Intern Med 1989; 110: 108. 124 Teehan BP, Sigler MH, Abies RI, Brown JM Recombinant human erythropoietin (epoetin alfa) in patients with predialysis renal failure: in AJ Erslev, JW Adamson, JW Eschbach, CG Winearls (eds): Erythropoietin: Molecular, Cellular and Clinical Biology. Baltimore, The Johns Hopkins University Press, 1991, p. 319. 125 Miller CB, Jones RJ, Piantadosi S, Abeloff MD, Spivak JL Decreased erythropoietin response in patients with the anemia of cancer. N Engl J Med 1990; 322: 1689. 126 Baer AN, Dessypris EN, Goldwasser E, Krantz SB Blunted erythropoietin response to anaemia in rheumatoid arthritis. Br J Haematol 1987; 66: 559. 127 Spivak JL, Barnes DC, Fuchs E, Quinn TC Serum immunoreactive erythropoietin in HIV-infected patients. JAMA 1989; 261: 3104. 128 Jelkmann W, Wolff M, Fandrey J Modulation of the production of erythropoietin by cytokines: In vitro studies and their clinical implications. Contrib Nephrol 1990; 87: 68. 129 Doweiko JP, Goldberg MA Erythropoietin therapy in cancer patients. Oncology 1991; 5: 31. 130 Pincus T, Olsen NJ, Russell I, Wolfe F, Harris ER, Schnitzer TJ, Boccagno JA, Krantz SB Multicenter study of recombinant human erythropoietin in correction of anemia in rheumatoid arthritis. Am J Med 1990; 89: 161. 131 Fischl M, Galpin JE, Levine JD, Groopman JE, Henery DH, Kennedy P, Miles S, Robbins W, Starrett B, Zalusky R, Abels RI, Tsai HC, Rudnick SA Recombinant human erythropoietin for patients with AIDS treated with zidovudine. N Engl J Med 1990; 322: 1488. 132 Oster W, Herrmann F, Gamm H, Zeile G, Lindemann A, Muller G, Brune T, Kraemer H-P, Mertelsmann R Erythropoietin for the treatment of anemia of malignancy associated with neoplastic bone marrow infiltration. J Clin One 1990; 8: 956. 133 Ludwig H, Fritz E, Kotzmann H, Hocker P, Gisslinger H, Barnas U Erythropoietin treatment of anemia associated with multiple myeloma. N Engl J Med 1990; 322: 1693. 134 Stein RS, Abels RI, Krantz SB Pharmacologic doses of recombinant human erythropoietin in the treatment of myelodysplastic syndromes. Blood 1991; 78: 1658. 135 Bowen D, Culligan D, Jacobs A The treatment of anaemia in the myelodysplastic syndromes with recombinant human erythropoietin. Br J Haematol 1991; 77: 419. 136 Hellstrom E, Birgegard G, Lockner D, Helmers C, Ost A, Wide L Treatment of myelodysplastic syndromes with recombinant human erythropoietin. Eur J Haematol 1991; 47: 355. 137 Stebler C, Tichelli A, Dazzi H, Gratwohl A, Nissen C, Speck B High dose recombinant human erythropoietin for treatment of anemia in myelodysplastic syndromes and paroxismal nocturnal hemoglobinuria: A pilot study. Exp Hematol 1990; 18: 1204. 138 Goodnough LT, Rudnick S, Price TH, Ballas SK, Collins ML, Crowley JP, Kosmin M, Kruskall MS, Lenes BA, Menitove JE, Silberstein LE, Smith KJ, Wallas CH., Abels R, Von Tress M Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy. N Engl J Med 1989; 321: 1163. 139 Gillon J, Bell K, Prescott RJ Autologous transfusion - Too far, too soon Vox Sang 1991; 61: 81. 140 Tasaki T, Ohto H, Hashimoto C, Abe R, Saitoh A, Kikuchi S Recombinant human erythropoietin for autologous blood donation: Effects on perioperative red-blood-cell and serum erythropoietin production. Lancet 1992; 339: 773. 141 Nonoguchi H, Abe K, Komatsu F Recombinant human erythropoietin for autologous blood donation. Lancet 1992; 339: 1483. 142 Thompson FL, Powers JS, Graber SE, Krantz SB Use of recombinant human erythropoietin to enhance autologous donation in a patient with multiple red cell-antibodies and the anemia of chronic disease. Am J Med 1991; 90: 398. Citing Literature Volume65, Issue3October 1993Pages 169-179 ReferencesRelatedInformation

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