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Dynamics of 5-hydroxytryptamine released from dopamine neurons in the caudate putamen of the rat

1995; Elsevier BV; Volume: 674; Issue: 1 Linguagem: Inglês

10.1016/0006-8993(95)00019-m

1872-6240

Brad P. Jackson, R. Mark Wightman,

Electrochemical sensors and biosensors

Fast-scan cyclic voltammetry has been used for the detection of 5-hydroxytryptamine (5-HT) in vivo. The applied potential waveform was previously optimized to maximize response times to concentration changes. This technique has been used to reinvestigate 5-HT release from striatal dopaminergic terminals after pharmacological pretreatment as reported by Stamford et al. [13]. Our results concur with those set forth by Stamford and further show that the dopamine transporter is responsible for 5-HT uptake in this experiment.