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The ACE Insertion/Deletion Polymorphism Is Not Associated With the Metabolic Syndrome (WHO Definition) in Brazilian Type 2 Diabetic Patients

2002; American Diabetes Association; Volume: 25; Issue: 12 Linguagem: Inglês

10.2337/diacare.25.12.2365

1935-5548

Luciana A. Costa, Luís Henrique Santos Canani, Ana Luiza Maia, Jorge Luiz Gross,

Renin-Angiotensin System Studies

The ACE gene has received substantial attention in recent years as candidate for a variety of diseases. The most common polymorphism in ACE gene is the insertion-deletion (I/D) polymorphism located in intron 16. The D allele is associated with higher levels of ACE, and it is considered to be a risk factor for development diseases such as coronary artery disease, hypertension, type 2 diabetes, or related complications (1). Recently, the presence of the metabolic syndrome (MS), according to World Health Organization (WHO) criteria (2), was associated with the D allele in Chinese patients with type 2 diabetes (3). The authors found that patients with MS were more often carriers of the D allele (DD/ID) than the patients without the MS (58 vs. 42%, P < 0.01). The prevalence …