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Measurements of Interleukin‐6 in Gingival Crevicular Fluid From Adults With Destructive Periodontal Disease

1993; Wiley; Volume: 64; Issue: 10 Linguagem: Inglês

10.1902/jop.1993.64.10.980

1943-3670

Milton Geivelis, Donald W. Turner, Ernest D. Pederson, B.L. Lamberts,

Endodontics and Root Canal Treatments

T his paper describes a study of whether or not the amounts of interleukin‐6 (IL‐6) in gingival crevicular fluid (GCF) are correlated with periodontal clinical measures. A sensitive ELISA was developed to measure IL‐6 in GCF. Two male and 3 female adult subjects with periodontal disease were examined at their first appointments, after 3 months, and after 6 months. Data were obtained on plaque index (PI), bleeding index (BI), probing depth (PD), and on the IL‐6 content of GCF samples from 16 sites per subject for a total of 240 measurements. Significant correlations were found between BI and IL‐6 ( P < 0.005) and between PD and IL‐6 ( P <0.05), but not between PI and IL6. Only 6 out of the 80 sites (in 3 of the 5 subjects) showed PD increases of at least 2 mm. However, for each of these 3 subjects, the amounts of IL‐6 in the GCF samples from these sites were markedly higher than the mean amounts of IL‐6 in the GCF samples from the remaining sites. These findings suggest that IL‐6 may be a useful indicator of periodontal disease, although more extensive longitudinal studies are needed to determine the real clinical value of this GCF component. J Periodontol 1993; 64:980–983.