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The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study

2015; Elsevier BV; Volume: 64; Issue: 7 Linguagem: Inglês

10.1016/j.metabol.2015.01.010

1532-8600

Anna Viitasalo, Mustafa Atalay, Jussi Pihlajamäki, Jarmo Jääskeläinen, Ayhan Korkmaz, Dorota Kamińska, Virpi Lindi, Timo A. Lakka,

Peroxisome Proliferator-Activated Receptors

Background There are no previous data on the association of PNPLA3 I148M polymorphism (rs738409) with circulating adipokines and myokines in children. Subjects/Methods Subjects were a population sample of 481 Caucasian children aged 6–8 years. We assessed circulating levels of irisin together with IL-6, TNF-α, leptin, high molecular weight (HMW)-adiponectin, alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) while the subjects were stratified according to PNPLA3 I148M variants. Results The PNPLA3 rs738409 polymorphism had a linear relationship with plasma levels of irisin after adjustment for age, sex and body height (p = 0.007) but it was not associated with circulating levels of interleukin- 6 (IL-6), tumor-necrosis factor α (TNF-α), leptin or HMW-adiponectin. Conclusion PNPLA3 148 M allele carriers had higher plasma levels of irisin than the non-carriers. This might be due to compensatory mechanism to limit early steatotic and inflammatory changes in the liver.