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Long Noncoding RNAs Usher In a New Era in the Biology of Enhancers

2013; Cell Press; Volume: 154; Issue: 6 Linguagem: Inglês

10.1016/j.cell.2013.08.028

1097-4172

Ulf Andersson Ørom, Ramin Shiekhattar,

RNA modifications and cancer

Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate transcription at distal promoters. Here, we address the latest advances made toward understanding the role of long noncoding RNA expression and the involvement of these RNAs in enhancer function through association with protein factors and modulation of chromatin structure. Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate transcription at distal promoters. Here, we address the latest advances made toward understanding the role of long noncoding RNA expression and the involvement of these RNAs in enhancer function through association with protein factors and modulation of chromatin structure.