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BIBTEX RIS

Prognostic value of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms and the susceptibility to gliomas in individuals from Southeast Brazil

2008; Research Foundation of Ribeirão Preto; Volume: 7; Issue: 1 Linguagem: Inglês

10.4238/vol7-1gmr415

ISSN

1676-5680

Autores

Giovanny R. Pinto, Fumi Yoshioka, Ricardo Luís Louzada da Silva, Carlos Clara, Marcelo José dos Santos, J.R.W. Almeida, Rommel Mário Rodríguez Burbano, Juan A. Rey, Cacilda Casartelli,

Tópico(s)

Molecular Biology Techniques and Applications

Resumo

The TP53 tumor suppressor gene codifies a protein responsible for preventing cells with genetic damage from growing and dividing by blocking cell growth or apoptosis pathways.A common single nucleotide polymorphism (SNP) in TP53 codon 72 (Arg72Pro) induces a 15-fold decrease of apoptosis-inducing ability and has been associated with susceptibility to human cancers.Recently, another TP53 SNP at codon 47 (Pro47Ser) was reported to have a low apoptosis-208 ©FUNPEC-RP www.funpecrp.com.

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