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OBESITY DUE TO THE SYNDROME OF NARCOLEPSY AND DIABETOGENIC HYPERINSULINISM: CLINICAL AND THERAPEUTIC OBSERVATIONS ON 252 PATIENTS*

1967; Wiley; Volume: 15; Issue: 8 Linguagem: Inglês

10.1111/j.1532-5415.1967.tb02307.x

1532-5415

H. J. Roberts,

Dietary Effects on Health

Journal of the American Geriatrics SocietyVolume 15, Issue 8 p. 721-743 Article OBESITY DUE TO THE SYNDROME OF NARCOLEPSY AND DIABETOGENIC HYPERINSULINISM: CLINICAL AND THERAPEUTIC OBSERVATIONS ON 252 PATIENTS* H. J. Roberts M.D., Corresponding Author H. J. Roberts M.D. West Palm Beach, FloridaDirector, Palm Beach Institute for Medical Research; Consulting Staff, St. Mary's Hospital, West Palm Beach.Address: Palm Beach Institute for Medical Research, Inc., 304 Twenty-Seventh Street, West Palm Beach, Florida, 33407.Search for more papers by this author H. J. Roberts M.D., Corresponding Author H. J. Roberts M.D. West Palm Beach, FloridaDirector, Palm Beach Institute for Medical Research; Consulting Staff, St. Mary's Hospital, West Palm Beach.Address: Palm Beach Institute for Medical Research, Inc., 304 Twenty-Seventh Street, West Palm Beach, Florida, 33407.Search for more papers by this author First published: August 1967 https://doi.org/10.1111/j.1532-5415.1967.tb02307.xCitations: 13 †From the Mannow Research Laboratory, Palm Beach Institute for Medical Research, West Palm Beach. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES 1Roberts, H. J.: Hyperlinks, narcolepsy and obesity—An important clinical triad, Clin. Res. 10: 234, 1962. 2Roberts, H. J.: The syndrome of narcolepsy and diabetogenic ("functional") hyperinsulinism, with special reference to obesity, diabetes, idiopathic edema, cerebral dysrhythmias and multiple sclerosis (200 patients), J. Am. Geriatrics Soc. 12: 926, 1964. 3Roberts, H. J.: The syndrome of narcolepsy and diabetogenic hyperinsulinism in the American Negro: its relationship to diabetes mellitus, obesity, dysrhythmias and accelerated cardiovascular disease, J. National M.A. 56: 18, 1964. 4Roberts, H. J.: The syndrome of narcolepsy and diabetogenic hyperinsulinism in the American Negro: important clinical, social and public health aspects, J. Am. Geriatrics Soc. 13: 852, 1965. 5Roberts, H. J.: Chronic refractory fatigue—An "organic" perspective: with emphasis upon the syndrome of narcolepsy and diabetogenic hyperinsulinism, Med. Times 92: 1144, 1964. 6Antar, M. A.; Ohlson, M. A., and Hodges, R. E.: Changes in retail market food supplies in the United States in the last seventy years in relation to the incidence of coronary heart disease, with special reference to dietary carbohydrates and essential fatty acids, Am. J. Clin. Nutr. 14: 169, 1964. 7Yoss, R. E., and Daly, D. D.: Narcolepsy, Med. Clin. N. America 44: 953, 1960. 8Bloom, W. L.: Inhibition of salt excretion by carbohydrate, Arch. Int. Med 109: 80 1962. 9Roberts, H. J.: An inquiry into the pathogenesis, rational treatment and prevention of multiple sclerosis, with emphasis upon the combined role of diabetogenic hyperinsulinism and recurrent edema, J. Am. Geriatrics Soc. 14: 586, 1966. 10Roberts, H. J.: On the etiology, rational treatment and prevention of multiple sclerosis, South. M. J. 59: 940, 1966. 11Roberts, H. J.: Spontaneous leg cramps and "restless legs" due to diabetogenic hyperinsulinism: observations on 131 patients, J. Am. Geriatrics Soc. 13: 602, 1965. 12Roberts, H. J.: Diabetogenic hyperinsulinism—A major etiology of ischemic heart disease, Clin. Res. 13: 28, 1965. 13Roberts, H. J.: Nocturnal angina pectoris (Letter), J.A.M.A. 198: 564, 1966. 14Roberts, H. J.: Café-au-lait spots (CALS), localized hypomelanosis (LH), and the white forelock (WF)—Clues to the syndrome of narcolepsy and diabetogenic hyperinsulinism, Clin. Res. 13: 267, 1965. 15Roberts, H. J.: Afternoon glucose tolerance testing: a key to the pathogenesis, early diagnosis and prognosis of diabetogenic hyperinsulinism, J. Am. Geriatrics Soc. 12: 423, 1964. 16Roth, J.; Glick, S. M.; Yalow, R. S., and Berson, S. A.: Secretion of human growth hormone: physiologic and experimental modification, Metabolism 12: 577, 1963. 17Zukoski, C. F., and Hume, D. M.: Direct measurement of adrenal gland secretion during insulin hypoglycemia in the dog, Clin. Res. 10: 38, 1962. 18Goldfien, A.; Moore, R.; Zileli, S.; Havens, L. L.; Boling, L., and Thorn, G. W.: Plasma epinephrine and norepinephrine levels during insulin-induced hypoglycemia in man, J. Clin. Endocrinol. & Metab. 21: 296, 1961. 19Streeten, D. H. P.; Gerstein, M. M.; Marmor, B. M., and Doisy, R. J.: Reduced glucose tolerance in elderly human subjects, Diabetes 14: 579, 1965. 20Lambert, A. E., and Hoet, J. J.: Diurnal pattern of plasma insulin concentration in the human, Diabetologia 2: 69, 1966. 21Bowen, A. J., and Reeves, R. L. (Virginia Mason Research Center, Seattle): Personal communication. 22Best, C. H., and Taylor, N. B.: The Physiological Basis of Medical Practice, 7th Ed. Baltimore, The Williams & Wilkins Co., 1961, p. 867. 23Gwinup, G.; Byron, R. C.; Roush, W. H.; Kruger, F., and Hamwi, G. J.: Effect of nibbling versus gorging on glucose tolerance, Lancet 2: 165, 1963. 24Cohn, C.; Pick, R., and Katz, L. N.: Effect of meal eating compared to nibbling upon atherosclerosis in chickens, Circ. Res. 9: 139, 1961. 25Roberts, H. J.: Effective long-term weight reduction: experiences with Metrecal, Am. J. Clin. Nutr. 8: 817, 1960. 26Roberts, H. J.: Long-term weight reduction in cardiovascular disease: experiences with a hypocaloric food mixture (Metrecal) in 78 patients, J. Am. Geriatrics Soc. 10: 308, 1962. 27Sanders, C. A.; Levinson, G. E.; Abelmann, W. H., and Freinkel, N.: Effect of exercise on the peripheral utilization of glucose in man, New England J. Med. 271: 220, 1964. 28Sussman, K. E.; Crout, J. R., and Marble, A.: Failure of warning in insulin-induced hypoglycemic reactions, Diabetes 12: 38, 1963. 29Fajans, S. S., and Conn, J. W.: Tolbutamide-induced improvement in carbohydrate tolerance of young people with mild diabetes mellitus, Diabetes 9: 83, 1960. 30Roberts, H. J.: Treatment of diabetic retinopathy with estrogens, J. Am. Geriatrics Soc. 9: 655, 1961. 31Roberts, H. J.: Unpublished data. 32Grodsky, G. M.; Karam, J. H.; Pavlatos, F. C., and Forsham, P. H.: Reduction by phenformin of excessive insulin levels after glucose loading in obese and diabetic subjects, Metabolism 12: 278, 1963. 33Salans, L. B., and Reaven, G. M.: Effect of oral hypoglycemic agents on serum insulin-like activity of patients with various degrees of carbohydrate intolerance, Metabolism 14: 26, 1965. 34Roberts, H. J.: Serial glucose, cholesterol and uric acid responses in "early chemical diabetes" before and after phenformin (Abstract), Diabetes 15: 544, 1966. 35Roberts, H. J.: Amphetamine (Letter), Lancet 2: 909, 1965. 36Berry, M. G.: Tobacco hypoglycemia, Ann. Int. Med. 50: 1149, 1959. 37Kuftinec, D. M., and Mayer, J.: Extreme sensitivity of obese hyperglycemic mice to caffeine and coffee, Metabolism 13: 1369, 1964. 38Field, J. B.; Williams, H. E., and Mortimer, G. E.: Studies on the mechanism of ethanol-induced hypoglycemia, J. Clin. Invest. 42: 497, 1963. Citing Literature Volume15, Issue8August 1967Pages 721-743 ReferencesRelatedInformation