Layer-by-Layer Assembled Gold Nanoparticles for siRNA Delivery
2009; American Chemical Society; Volume: 9; Issue: 5 Linguagem: Inglês
10.1021/nl9003865
ISSN1530-6992
AutoresAsmaa M. Elbakry, Alaa A. Zaky, Renate Liebl, Reinhard Rachel, Achim Goepferich, Miriam Breunig,
Tópico(s)Gold and Silver Nanoparticles Synthesis and Applications
ResumoAlthough uptake into cells is highly complex and regulated, heterogeneous particle collectives are usually employed to deliver small interfering RNA (siRNA) to cells. Within these collectives, it is difficult to accurately identify the active species, and a decrease in efficacy is inherent to such preparations. Here, we demonstrate the manufacture of uniform nanoparticles with the deposition of siRNA on gold in a layer-by-layer approach, and we further report on the cellular delivery and siRNA activity as functions of surface properties.
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