First intention high frequency oscillatory ventilation with lung volume optimization in very low birth weight newborns — 9 years experience
2008; Elsevier BV; Volume: 84; Linguagem: Inglês
10.1016/j.earlhumdev.2008.09.050
ISSN1872-6232
AutoresLaura Martins, Nuno Carvalho, Raquel Marta, Dora Gomes, José Nona, Odília Nascimento, Agustín Valido,
Tópico(s)Congenital Diaphragmatic Hernia Studies
ResumoA variety of ventilation modes are available for the newborn. Although, there have been randomised trials assessing certain modes, these have generally only included prematurely born infants with RDS or infants with severe respiratory failure. Meta-analysis of the results of those trials has demonstrated that neither patient triggered nor high frequency oscillatory ventilation is advantageous for the prematurely born infant with RDS, but extracorporeal membrane oxygenation increases survival in infants with severe respiratory failure. Appropriately designed studies are required to determine the role of newer ventilation modes and whether forms of respiratory support avoiding intubation are less injurious to the lungs. Research should also focus on infants with other respiratory disorders, particularly BPD. Prior to further randomised trials being undertaken, it is essential that the optimum method of applying each ventilator mode is identified and it is clearly understood whether differences in ventilator/oscillator performance influence outcome.
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