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Structure–activity relationships of novel N-acyloxy-1,4-dihydropyridines as P-glycoprotein inhibitors

2007; Elsevier BV; Volume: 15; Issue: 15 Linguagem: Inglês

10.1016/j.bmc.2007.05.036

1464-3391

B. VOIGT, Claudius Coburger, Joséf Monár, Andreas Hilgeroth,

Pharmacological Effects and Toxicity Studies

Series of novel N-acyloxy-1,4-dihydropyridines have been synthesized and evaluated as P-glycoprotein inhibitors in an in vitro assay to estimate their potential to act as multidrug resistance modulators in cancer cells. Structure–activity relationships are discussed and prove a significant and regiospecific influence of certain functional groups.