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Stereotactic Body Radiotherapy Is Effective Salvage Therapy for Patients With Prior Radiation of Spinal Metastases

2008; Elsevier BV; Volume: 74; Issue: 3 Linguagem: Inglês

10.1016/j.ijrobp.2008.09.020

1879-355X

Arjun Sahgal, Christopher P. Ames, Dean Chou, Lijun Ma, Kim Huang, Wei Xu, Cynthia T. Chin, Vivan Weinberg, Cynthia Chuang, Phillip Weinstein, David A. Larson,

Spinal Fractures and Fixation Techniques

Purpose To provide actuarial outcomes and dosimetric data for spinal/paraspinal metastases, with and without prior radiation, treated with stereotactic body radiotherapy (SBRT). Methods and Materials A total of 39 consecutive patients (60 metastases) were treated with SBRT between April 2003 and August 2006 and retrospectively reviewed. In all, 23 of 60 tumors had no previous radiation (unirradiated) and 37/60 tumors had previous irradiation (reirradiated). Of 37 reirradiated tumors, 31 were treated for "salvage" given image-based tumor progression. Local failure was defined as progression by imaging and/or clinically. Results At last follow-up, 19 patients were deceased. Median patient survival time measured was 21 months (95% CI=8–27 months), and the 2-year survival probability was 45%. The median total dose prescribed was 24 Gy in three fractions prescribed to the 67% and 60% isodose for the unirradiated and reirradiated cohorts, respectively. The median tumor follow-up for the unirradiated and reirradiated group was 9 months (range, 1–26) and 7 months (range, 1-48) respectively. Eight of 60 tumors have progressed, and the 1- and 2-year progression-free probability (PFP) was 85% and 69%, respectively. For the salvage group the 1 year PFP was 96%. There was no significant difference in overall survival or PFP between the salvage reirradiated vs. all other tumors treated ( p = 0.08 and p = 0.31, respectively). In six of eight failures the minimum distance from the tumor to the thecal sac was ≤1 mm. Of 60 tumors treated, 39 have ≥6 months follow-up and no radiation-induced myelopathy or radiculopathy has occurred. Conclusion Spine SBRT has shown preliminary efficacy and safety in patients with image-based progression of previously irradiated metastases.