Two alexines [3-hydroxymethyl-1,2,7-trihydroxypyrrolizidines] from Castanospermum australe
1990; Elsevier BV; Volume: 29; Issue: 1 Linguagem: Inglês
10.1016/0031-9422(90)89022-2
ISSN1873-3700
AutoresRobert J. Nash, Linda E. Fellows, Janet V. Dring, George W. J. Fleet, Aarti Girdhar, Nigel G. Ramsden, J.M. Peach, Mervyn P. Hegarty, A. M. Scofield,
Tópico(s)Phytochemistry and Biological Activities
ResumoTwo new alexines have been isolated from Castanospermum australe. The structure of 1,7a-diepialexine was firmly established by X-ray crystallographic analysis of the corresponding 1,7-isopropylidene derivative. The structure of the second new alexine was tentatively assigned as 7,7a-diepialexine or its enantiomer. The abilities of naturally occurring alexines to inhibit mouse gut disaccharidase and fungal glucan 1,4-α-glucosidase are compared.
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