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The Dissolution Hate and the Ohal Absorption Eficificy of Selected Salicylates from Lipid Drug Delivery Systers

1976; Marcel Dekker; Volume: 2; Issue: 6 Linguagem: Inglês

10.3109/03639047609051912

0095-5183

Satishchandra P. Patel, Charles I. Jarowski,

Drug Solubulity and Delivery Systems

Abstractp-Sitosterol, cholesterol and its acetate and n-aecylate esters were used. in 3, 4.5 and 6-fola excess with salicylic acia, salicylamide, aspirin and metnyl sallcylate with and without lactsse. Dissolution stuaies were conaucted in simulatea gastrointestinal fluios with and without sodium cnolate. Tne in vitro aissolution rate of salicylic &c10 was markedly enhanced in the presence of the Dile salt. Although the aissolution rates of the salicylates from the lipid systems were significantly reduced, the rate and extent of appearance of salicylate in the urine of two test subjects were similar to plain salicylic acia. The urine recovery of free salicylate seemed to be increased when the lipid vehicle was cholesteryl n-becylate.