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Phytochemical screening and anti-inflammatory activity of Cnidoscolus quercifolius (Euphorbiaceae) in mice
2014; Medknow; Volume: 6; Issue: 4 Linguagem: Inglês
10.4103/0974-8490.138290
ISSN0976-4836
AutoresJackson Roberto Guedes da Silva Almeida, Leonor Gomes, Teresinha Maria de Andrade, JulianeCabral Silva, Julianeli Tolentino de Lima, Lucindo José Quintans‐Júnior,
Tópico(s)Phytochemistry and biological activity of medicinal plants
ResumoPharmacognosy Research,2014,6,4, 345-349.DOI:10.4103/0974-8490.138290Authors:Leandra Macedo de Araujo Gomes, Leandra Macedo de Araujo Gomes, Juliane Cabral Silva, Julianeli Tolentino de Lima, Lucindo Jose Quintans-Junior, and Jackson Roberto Guedes da Silva Almeida Author(s) affiliations:Leandra Macedo de Araujo Gomes1, Thayne Mayra Dantas de Andrade1, Juliane Cabral Silva1, Julianeli Tolentino de Lima1, Lucindo Jose Quintans-Junior2, Jackson Roberto Guedes da Silva Almeida1 1Collegiate of Pharmaceutical Sciences, Center of Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco 56.304-205, Brazil. 2Department of Physiology, Federal University of Sergipe, 49.100-000, São Cristóvão, Sergipe, Brazil. Abstract:Background: Cnidoscolus quercifolius is a species popularly known as "favela" and "faveleira", and belonging to the Caatinga biome (semi-arid vegetation, Brazil), where is used in folk medicine as an anti-inflammatory. Objective: The aim was to evaluate the anti-inflammatory effect of the ethanolic extract from barks (Cqb-EtOH) and leaves (Cql-EtOH) of C. quercifolius in mice using experimental models of inflammation. Materials and Methods: The preliminary phytochemical analysis of the ethanolic extract was performed. The activity was evaluated by paw edema induced by carrageenan and leukocytes migration to the peritoneal cavity induced by carrageenan methods. Results: A preliminary analysis of Cqb-EtOH revealed that it contained coumarins, flavonoids, monoterpenes/diterpenes and naphthoquinones, while the Cql-EtOH showed positive reaction to coumarins, anthracene derivatives, flavonoids, lignans and triterpenes/steroids. Cqb-EtOH and Cql-EtOH (100, 200 and 400 mg/kg) inhibited significantly (P < 0.01) the increase in the edema volume after administration of carrageenan. In the peritonitis test, acute pretreatment with Cqb-EtOH and Cql-EtOH (100, 200 and 400 mg/kg) inhibited the leukocyte migration. Conclusions: It can be concluded that extracts from the barks and leaves of C. quercifolius have anti-inflammatory activity, which supports the popular use of this plant to treat inflammation. Thus, extracts has significant anti-inflammatory properties, which are related probably to inhibition of release of mediators of the inflammatory process. Keywords:Cnidoscolus quercifolius, Euphorbiaceae, Inflammation, Medicinal plantsView:PDF (826 KB)
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