Artigo Produção Nacional Revisado por pares

Antidepressant-like effect of m-trifluoromethyl-diphenyl diselenide in the mouse forced swimming test involves opioid and serotonergic systems

2011; Elsevier BV; Volume: 658; Issue: 2-3 Linguagem: Inglês

10.1016/j.ejphar.2011.02.039

ISSN

1879-0712

Autores

César Augusto Brüning, Ana Cristina Guerra Souza, Bibiana Mozzaquatro Gai, Gilson Zeni, Cristina W. Nogueira,

Tópico(s)

Sulfur-Based Synthesis Techniques

Resumo

Serotonergic and opioid systems have been implicated in major depression and in the action mechanism of antidepressants. The organoselenium compound m-trifluoromethyl-diphenyl diselenide (m–CF3–PhSe)2 shows antioxidant and anxiolytic activities and is a selective inhibitor of monoamine oxidase A activity. The present study was designed to investigate the antidepressant-like effect of (m–CF3–PhSe)2 in female mice, employing the forced swimming test. The involvement of the serotonergic and opioid systems in the antidepressant-like effect of (m–CF3–PhSe)2 was appraised. (m–CF3–PhSe)2 at doses of 50 and 100 mg/kg (p.o.) exhibited antidepressant-like action in the forced swimming test. The effect of (m–CF3–PhSe)2 (50 mg/kg p.o.) was prevented by pretreatment of mice with WAY100635 (0.1 mg/kg, s.c. a selective 5-HT1A receptor antagonist), ritanserin (4 mg/kg, i.p., a non-selective 5HT2A/2C receptor antagonist), ondansetron (1 mg/kg, i.p., a selective 5-HT3 receptor antagonist) and naloxone (1 mg/kg, i.p., a non-selective antagonist of opioid receptors). These results suggest that (m–CF3–PhSe)2 produced an antidepressant-like effect in the mouse forced swimming test and this effect seems most likely to be mediated through an interaction with serotonergic and opioid systems.

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