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Area detectors for protein crystallography at storage rings

1984; Elsevier BV; Volume: 222; Issue: 1-2 Linguagem: Inglês

10.1016/0167-5087(84)90538-6

1872-9606

U. W. Arndt,

Particle Detector Development and Performance

Abstract Beam lines are now coming into use at which the monochromatic X-ray flux at the sample is in excess of 10 12 8 keV photons mm − s − . In principle, these allow complete three-dimensional data collection from 100 A unit cell protein crystals in a few minutes. The relationship between maximum count rate, dynamic range and DQE of televesion area detectors is examined and it is shown that these detectors are just able to cope with the necessary counting rates by stretching present-day technology. The most serious demands are posed by the very large data volumes and rates, as there is little possibility of real-time data-contraction or processing. The situation is somewhat eased by using shorter wavelength X-radiation, which leads to lower data rates while having advantages from the point of view of radiation damage and absorption corrections.