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A comparison of the efficacy of azithromycin and clarithromycin in oral therapy of experimental airborne legionnaires' disease

1993; Oxford University Press; Volume: 31; Issue: suppl E Linguagem: Inglês

10.1093/jac/31.suppl_e.171

1460-2091

R. B. Fitzgeorge, Steve Lever, A. Baskerville,

Chronic Obstructive Pulmonary Disease (COPD) Research

The activities of two new macrolides, azithromycin and clarithromycin, were compared in an aerosol-infected guinea-pig model of legionnaires' disease. The results of this study indicate that a low oral dose of azithromycin (3.6 mg/kg) administered once daily gives 100% survival in Legionella pneumophila -infected animals. An eight-fold higher dose of clarithromycin (28.8mg/kg) given twice-daily was required to achieve the same effect. Similarly, azithromycin was more effective than clarithromycin in preventing pyrexia and in reducing numbers of bacteria and lesions in the lung.