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Incidence of Contralateral Germ Cell Testicular Tumors in South Europe:: Report of the Experience at 2 Spanish University Hospitals and Review of the Literature

2004; Lippincott Williams & Wilkins; Volume: 171; Issue: 1 Linguagem: Inglês

10.1097/01.ju.0000099893.79138.55

1527-3792

Josep Tabernero, Luis Paz‐Ares, Ramón Salazar, P. Lianes, José Guerra, Joan Borràs, Humberto Villavicencio, O Leiva, H. Cortés-Funes,

Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jan 2004Incidence of Contralateral Germ Cell Testicular Tumors in South Europe:: Report of the Experience at 2 Spanish University Hospitals and Review of the Literature JOSEP TABERNERO, LUÍS PAZ-ARES, RAMON SALAZAR, PILAR LIANES, JOSÉ A. GUERRA, JOAN BORRÁS, HUMBERTO VILLAVICENCIO, OSCAR LEIVA, and HERNÁN CORTÉS-FUNES JOSEP TABERNEROJOSEP TABERNERO More articles by this author , LUÍS PAZ-ARESLUÍS PAZ-ARES More articles by this author , RAMON SALAZARRAMON SALAZAR More articles by this author , PILAR LIANESPILAR LIANES More articles by this author , JOSÉ A. GUERRAJOSÉ A. GUERRA More articles by this author , JOAN BORRÁSJOAN BORRÁS More articles by this author , HUMBERTO VILLAVICENCIOHUMBERTO VILLAVICENCIO More articles by this author , OSCAR LEIVAOSCAR LEIVA More articles by this author , and HERNÁN CORTÉS-FUNESHERNÁN CORTÉS-FUNES More articles by this author View All Author Informationhttps://doi.org/10.1097/01.ju.0000099893.79138.55AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The crude and cumulative incidence of contralateral germ cell testicular tumors (GCTTs) is between 1% to 5% and 3% to 6% at 10 to 15 years in previously reported studies. To evaluate the real incidence of a second GCTT in a southern European population the medical records of 623 patients with GCTT successfully treated between 1976 and 1993 at 2 university hospitals were reviewed. Materials and Methods: All patients had been treated with standard treatment strategies according to disease stage and diagnosis year. Contralateral biopsy at GCTT diagnosis was not performed in any patient. Only those with a survival of 1 year or greater were included. In addition to the imaging and biochemical (tumor markers) procedures used to diagnose disease relapse, physical examination of the contralateral testis and/or testicular ultrasound was done yearly. Results: At a median followup of 8.6 years (range 2 to 19.7) 6 patients (1%) had a contralateral GCTT, which was synchronous in 1 and metachronous in 5. The cumulative risk of a contralateral GCTT was 1.2% (95% CI 0.1% to 2.3%) at 15 years and it did not depend on the treatment for the first GCTT. Conclusions: The incidence of contralateral GCTT in our series was lower than expected compared with other published series. This finding mirrors the lower incidence of GCTT in the general population in our country than in other areas with a higher incidence of contralateral GCTT. Therefore, contralateral testicular biopsy at initial diagnosis is not mandatory in our experience. References 1 : Possible carcinoma-in-situ of the testis. Lancet1972; 2: 516. Google Scholar 2 : The 4th Copenhagen Workshop on Carcinoma in situ and Cancer of the Testis: concluding remarks. APMIS1998; 106: 259. Google Scholar 3 : Cisplatin-based chemotherapy changes the incidence of bilateral testicular cancer. Ann Surg Oncol1997; 4: 342. Google Scholar 4 : Risk of bilateral testicular germ cell cancer in Denmark: 1960–1984. J Natl Cancer Inst1991; 83: 1391. Google Scholar 5 : Second cancer risk following testicular cancer: a follow-up study of 1,909 patients. J Clin Oncol1993; 11: 415. Google Scholar 6 : Bilateral germ cell testicular tumors in New Zealand: experience in Auckland and Christchurch 1978–1994. 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Google Scholar From the Medical Oncology Service, Hospital de Sant Pau (JT, RS) and Urology Service, Fundació Puigvert (HV), Barcelona, Medical Oncology (LP-A, PL, JAG, HC-F) and Urology (OL) Services, Hospital Universitario Doce de Octubre, Madrid and Tarragona Cancer Registry (JB), Tarragona, Spain© 2004 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byBulent A, Taner D, Tolga T, Sertac Y, Celik T, Ferruh Z and Haluk O (2018) Bilateral Testicular Germ Cell Tumors in Turkey: Increase in Incidence in Last Decade and Evaluation of Risk Factors in 30 PatientsJournal of Urology, VOL. 178, NO. 1, (129-133), Online publication date: 1-Jul-2007.HUYGHE E, SOULIE M, ESCOURROU G, MIEUSSET R, PLANTE P and THONNEAU P (2018) CONSERVATIVE MANAGEMENT OF SMALL TESTICULAR TUMORS RELATIVE TO CARCINOMA IN SITU PREVALENCEJournal of Urology, VOL. 173, NO. 3, (820-823), Online publication date: 1-Mar-2005. Volume 171Issue 1January 2004Page: 164-167 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.Keywordsgerminomabiopsytestistesticular neoplasmsneoplasms, second primaryMetricsAuthor Information JOSEP TABERNERO More articles by this author LUÍS PAZ-ARES More articles by this author RAMON SALAZAR More articles by this author PILAR LIANES More articles by this author JOSÉ A. GUERRA More articles by this author JOAN BORRÁS More articles by this author HUMBERTO VILLAVICENCIO More articles by this author OSCAR LEIVA More articles by this author HERNÁN CORTÉS-FUNES More articles by this author Expand All Advertisement PDF downloadLoading ...