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Immune activation alters cellular and humoral responses to yellow fever 17D vaccine

2014; American Society for Clinical Investigation; Volume: 124; Issue: 7 Linguagem: Inglês

10.1172/jci75429

1558-8238

Enoch Muyanja, Aloysius Ssemaganda, Pearline Ngauv, Rafael Cubas, Hélène Perrin, Divya Srinivasan, Glenda Canderan, Benton Lawson, Jakub Kopycinski, Amanda S. Graham, Dawne K. Rowe, Michaela J. Smith, Sharon Isern, Scott Michael, Guido Silvestri, Thomas H. Vanderford, Erika Castro, Giuseppe Pantaleo, Joel Singer, Jill Gillmour, Noah Kiwanuka, Annet Nanvubya, Claudia Schmidt, Josephine Birungi, Josephine H. Cox, Elias K. Haddad, Pontiano Kaleebu, Patricia Fast, Rafick‐Pierre Sékaly, Lydie Trautmann,

Viral Infections and Outbreaks Research

Background. Defining the parameters that modulate vaccine responses in African populations will be imperative to design effective vaccines for protection against HIV, malaria, tuberculosis, and dengue virus infections. This study aimed to evaluate the contribution of the patient-specific immune microenvironment to the response to the licensed yellow fever vaccine 17D (YF-17D) in an African cohort.