Induction and stimulation of 92-kDa gelatinase / type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor α
1990; Elsevier BV; Volume: 171; Issue: 2 Linguagem: Inglês
10.1016/0006-291x(90)91190-4
ISSN1090-2104
AutoresYasunori Okada, Hiroyuki Tsuchiya, Hirokazu Shimizu, Katsuro Tomita, Isao Nakanishi, Hiroshi Sato, Motoharu Seiki, Kyoko Yamashita, Taro Hayakawa,
Tópico(s)Blood Coagulation and Thrombosis Mechanisms
ResumoProduction of a 92-kDa gelatinase / type IV collagenase and tissue inhibitor of metalloproteinases (TIMP) was investigated with human sarcoma cell lines. Among the cytokines and growth factors examined, only human recombinant tumor necrosis factor α (TNFα) induced and stimulated the proteinase with concomitant increase in TIMP expression, but matrix metalloproteinase 2 (72-kDa gelatinase / type IV collagenase) expression was unchanged. These data suggest that gene expression of the two metalloproteinases is regulated in a different fashion and TNFα may be important to allow cancer cells to be more invasive and metastatic.
Referência(s)