Novel in vitro and mathematical models for the prediction of chemical toxicity
2012; Oxford University Press; Volume: 2; Issue: 1 Linguagem: Inglês
10.1039/c2tx20031g
ISSN2045-4538
AutoresDominic P. Williams, Rebecca J. Shipley, Marianne J. Ellis, S. David Webb, John Ward, Iain Gardner, Stuart Creton,
Tópico(s)Pharmacogenetics and Drug Metabolism
ResumoThe focus of much scientific and medical research is directed towards understanding the disease process and defining therapeutic intervention strategies. The scientific basis of drug safety is very complex and currently remains poorly understood, despite the fact that adverse drug reactions (ADRs) are a major health concern and a serious impediment to development of new medicines. Toxicity issues account for ∼21% drug attrition during drug development and safety testing strategies require considerable animal use. Mechanistic relationships between drug plasma levels and molecular/cellular events that culminate in whole organ toxicity underpins development of novel safety assessment strategies. Current
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