How Does Trichinella spiralis Make Itself at Home?
1998; Elsevier BV; Volume: 14; Issue: 8 Linguagem: Inglês
10.1016/s0169-4758(98)01287-3
ISSN1873-1473
Autores Tópico(s)Genetics, Aging, and Longevity in Model Organisms
ResumoThe nurse cell-parasite complex of Trichinella spiralis is unlike anything else in Nature. It is derived from a normal portion of striated skeletal muscle cell and develops in a matter of 15 to 20 days after the larva invades that cell type. What are the molecular mechanisms at work that result in this unique relationship? Here, Dickson Despommier presents a hypothesis to account for its formation, in which secreted tyvelosylated proteins of the larva play a central role. These proteins are always present in the intracellular niche of the larva from Day 7 after infection and may be responsible for redirecting host genomic expression, leading to nurse cell formation.
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