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In vitro activity of 11 antibiotics against 74 anaerobes isolated from pediatric intra-abdominal infections

2005; Elsevier BV; Volume: 12; Issue: 2 Linguagem: Inglês

10.1016/j.anaerobe.2005.11.004

1095-8274

Ellie J. C. Goldstein, Diane M. Citron, Sagar A. Vaidya, Yumi A. Warren, Kerin L. Tyrrell, C. Vreni Merriam, Helen T. Fernandez,

Antibiotic Resistance in Bacteria

The in vitro activity of 11 antimicrobials was tested against 74 recent anaerobic isolates obtained from pretreatment cultures in pediatric patients with complicated intra-abdominal infections using the CLSI M11-A-6 agar dilution method. Carbapenems, beta-lactamase inhibitor combinations and metronidazole retained good activity, while all Bacteroides fragilis group species produced beta-lactamase and were penicillin resistant and 43% were either intermediately susceptible or resistant to clindamycin. Cefoxitin had moderate activity against B. fragilis but poor activity against Bacteroides thetaiotaomicron and other B. fragilis group isolates.