Genetic characterization of Tribeč virus and Kemerovo virus, two tick-transmitted human-pathogenic Orbiviruses
2011; Elsevier BV; Volume: 423; Issue: 1 Linguagem: Inglês
10.1016/j.virol.2011.11.020
ISSN1096-0341
AutoresMeik Dilcher, Lekbira Hasib, Marcus Lechner, Nicolas Wieseke, Martin Middendorf, Manja Marz, Andrea U. Koch, Martin Spiegel, Gerhard Dobler, Frank T. Hufert, Manfred Weidmann,
Tópico(s)Vector-borne infectious diseases
ResumoWe determined the complete genome sequences of Tribeč virus (TRBV) and Kemerovo virus (KEMV), two tick-transmitted Orbiviruses that can cause diseases of the central nervous system and that are currently classified into the Great Island virus serogroup. VP2 proteins of TRBV and KEMV show very low sequence similarity to the homologous VP4 protein of tick-transmitted Great Island virus (GIV). The new sequence data support previous serological classification of these Orbiviruses into the Kemerovo serogroup, which is different from the Great Island virus serogroup. Genome segment 9 of TRBV and KEMV encodes several overlapping ORF's in the + 1 reading frame relative to VP6(Hel). A co-phylogenetic analysis indicates a host switch from insect-borne Orbiviruses toward Ixodes species, which is in disagreement with previously published data.
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