Familial and sporadic schizophrenia: visual evoked potential differences
1988; Elsevier BV; Volume: 24; Issue: 7 Linguagem: Inglês
10.1016/0006-3223(88)90261-2
ISSN1873-2402
AutoresSteven B. Schwarzkopf, R.M. Chapman, Maureen Jimenez, Laurette Treglia, Catherine Kane, J. Steven Lamberti, Henry A. Nasrallah,
Tópico(s)Neural dynamics and brain function
ResumoIntroduction The hete~genei~ of ~~zop~nia has been iong recognized (Tsuang 1975), and various methods of subclassification have been developed, including combinations of clinical and biological measures (Jeste 1982; Buchsbaum et al. 1983). Elec~ophysiological literature relevant to subtyping in schizophrenia includes: findings of varying electrodermal responses of patients depending on the severity of emotional withdrawal and disorganization (Straube 1979; Bernstein et al. 1981); evoked potential differences between chronic and acute patients, patients with differing clinical symptoms (Landau et al. 1975; Shagass 1980), and familial versus nonfamilial patients (Romani et al. 1986); lateral asymmetries of electroencephalogram (EEG) variables in patients with specific clinicai symptoms (Serafetinides et al. 198 1); and different patterns of evoked potentials and EEG variables in neuroleptic-responsive and unresponsive patients (Saletu 1977; hi1 et al. 1981). The utility of the familial/sporadic distinction in psychosis has recently been reviewed and may be a useful strategy for determining more homogeneous subgroups (Lewis et al. 1987). In the current study, we tested the hypothesis that visual evoked potential (VEP) latencies are prolonged in psychotic patients with a positive family history of psychosis (FH PGS) when compared to equaliy ill patients without a family history of psychosis (FH NEG).
Referência(s)