Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists
1996; Lippincott Williams & Wilkins; Volume: 7; Issue: 15 Linguagem: Inglês
10.1097/00001756-199611040-00067
ISSN1473-558X
AutoresKim Fisher, Terence J. Coderre,
Tópico(s)Healthcare and Venom Research
ResumoTHE present study examined the mGluR subtypes involved in (1S,3R)-ACPD-induced spontaneous nociceptive behaviours (SNB) by administering the following selective agonists by the intrathecal (i.t.) route: (RS)-DHPG, trans-ADA. (Group I; mGluR1/5 and mGluR5, respectively), (1S,3S)-ACPD, (2R,4R)-APDC (Group II), and L-AP4 (Group III). (RS)-DHPG administration induced SNB that were of significantly greater intensity and longer duration than those induced by an equal dose of (1S,3R)-ACPD. No other agonists produced SNB, except (1S,3S)-ACPD, which may be attributable to a nonselective action at mGluRl. Intrathecal treatment with the mGluR antagonist (+)-MCPG or the NMDA antagonist D-AP5 prior to (RS)-DHPG administration dose-dependently reduced SNB. It is suggested that a possible interaction between NMDA and mGluRl is a critical event in the maintenance of persistent nociception.
Referência(s)