Pd-Catalyzed Kumada−Corriu Cross-Coupling Reactions at Low Temperatures Allow the Use of Knochel-type Grignard Reagents
2007; American Chemical Society; Volume: 129; Issue: 13 Linguagem: Inglês
10.1021/ja070830d
ISSN1943-2984
AutoresRubén Martı́n, Stephen L. Buchwald,
Tópico(s)Chemical synthesis and alkaloids
ResumoA catalyst system able to operate at temperatures as low as −65 °C for the Pd-catalyzed Kumada−Corriu cross-coupling reaction is described. This unprecedented level of activity allows the use of highly functionalized (Knochel-type) Grignard reagents. Additionally, the tolerance of the protocol toward a wide variety of functional groups allows for the synthesis of valuable compounds, including heterocyclic or polyfluoro biaryls.
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