Matrikines in the regulation of extracellular matrix degradation
2004; Elsevier BV; Volume: 87; Issue: 3-4 Linguagem: Inglês
10.1016/j.biochi.2004.10.006
ISSN1638-6183
AutoresF X Maquart, Georges Bellon, Sylvie Brassart‐Pasco, J.C. Monboisse,
Tópico(s)Peptidase Inhibition and Analysis
ResumoThe term "matrikines" was coined for designating peptides liberated by partial proteolysis of extracellular matrix macromolecules, which are able to regulate cell activities. Among these peptides, some of them may modulate proliferation, migration, protease production, or apoptosis. In this review, we summarize the activity of matrikines derived from elastin and interstitial or basement membrane collagens on the regulation of matrix metalloproteinases expression and/or activation, and on the plasminogen/plasmin system. Due to their activity, matrikines may play a significant role in physiological or pathological processes such as wound healing or tumor invasion.
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