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Hepatic fine structural changes and microsomal hypofunction in Walker tumor-bearing rats

1972; Wiley; Volume: 29; Issue: 3 Linguagem: Inglês

10.1002/1097-0142(197203)29

1097-0142

J. D. Khandekar, D Dardachti, BD Garg, Béatriz Tuchweber, Kálmán Kovács,

Drug Transport and Resistance Mechanisms

Rats bearing intramuscular Walker tumor transplants, but exhibiting no evidence of circulatory insufficiency, were studied at weekly intervals, for 28 days. Hexobarbital anesthesia and zoxazolamine paralysis were prolonged in these animals, suggesting hepatic microsomal insufficiency. These changes were associated with progressive rough-surfaced endoplasmic reticulum (RER) dilatation, disorganization, disruption, and degranulation, as well as proliferation of the smooth-surfaced endoplasmic reticulum (SER). It remains to be established whether the livers of cancer patients also display similar abnormalities, yet such hepatic changes might be responsible for aberrations in hormone and drug metabolism.