Voltar
Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Enhanced RNA and protein synthesis in vitro in astrocytes derived from rats in the early stage of experimental hepatogenic encephalopathy

2009; Wiley; Volume: 70; Issue: 4 Linguagem: Inglês

10.1111/j.1600-0404.1984.tb00829.x

ISSN

1600-0404

Autores

Jan Albrecht,

Tópico(s)

Prion Diseases and Protein Misfolding

Resumo

Abstract– Astroglia-enriched cell fractions derived from rats with the early symptoms of hepatogenic enecephalopathy (HE) following treatment with thioacetamide, showed an increase above control ability to incorporate radioactive precursors into RNA and proteins. These results lend support to the idea that overall stimulation of macromolecular syntheses is an important aspect of astroglial reaction preceding the appearance in astrocytes of progressive morphological changes characterizing more advanced stages of HE.

Referência(s)