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Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

2013; Elsevier BV; Volume: 122; Issue: 17 Linguagem: Inglês

10.1182/blood-2013-05-500801

1528-0020

Asim Saha, Kazutoshi Aoyama, Patricia A. Taylor, Brent H. Koehn, Rachelle G. Veenstra, Angela Panoskaltsis‐Mortari, David H. Munn, William J. Murphy, Miyuki Azuma, Hideo Yagita∥, Brian T. Fife, Mohamed H. Sayegh, Nader Najafian, Gèrard Socié, Rafi Ahmed, Gordon J. Freeman, Arlene H. Sharpe, Bruce R. Blazar,

T-cell and B-cell Immunology

Key Points PD-L1 and PD-L2 expression were upregulated during GVHD, whereas PD-1/PD-L1 was more critical than PD-1/PD-L2 in downregulating GVHD. Our data provide new insight into the differential roles of host PD-L1 and PD-L2 and associated mechanisms in controlling GVHD.