Generalized Large Vessel Arteritis Visualized by 18 Fluorodeoxyglucose-Positron Emission Tomography
2003; Lippincott Williams & Wilkins; Volume: 107; Issue: 6 Linguagem: Inglês
10.1161/01.cir.0000050689.89407.87
ISSN1524-4539
AutoresMartin Wenger, R. Gasser, Eveline Donnemiller, Hermann Erler, Hartmut Glossmann, Josef R. Patsch, Roy Moncayo, Michael Schirmer,
Tópico(s)Sarcoidosis and Beryllium Toxicity Research
ResumoHomeCirculationVol. 107, No. 6Generalized Large Vessel Arteritis Visualized by 18Fluorodeoxyglucose-Positron Emission Tomography Free AccessReview ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessReview ArticlePDF/EPUBGeneralized Large Vessel Arteritis Visualized by 18Fluorodeoxyglucose-Positron Emission Tomography Martin Wenger, Rudolf Gasser, Eveline Donnemiller, Hermann Erler, Hartmut Glossmann, Josef R. Patsch, Roy Moncayo and Michael Schirmer Martin WengerMartin Wenger From the Departments of Nuclear Medicine (M.W., E.D., H.E., R.M.) and Internal Medicine (R.G., J.R., M.S.), and the Institute of Biochemical Pharmacology (H.G.), Innsbruck University Hospital, Innsbruck, Austria. , Rudolf GasserRudolf Gasser From the Departments of Nuclear Medicine (M.W., E.D., H.E., R.M.) and Internal Medicine (R.G., J.R., M.S.), and the Institute of Biochemical Pharmacology (H.G.), Innsbruck University Hospital, Innsbruck, Austria. , Eveline DonnemillerEveline Donnemiller From the Departments of Nuclear Medicine (M.W., E.D., H.E., R.M.) and Internal Medicine (R.G., J.R., M.S.), and the Institute of Biochemical Pharmacology (H.G.), Innsbruck University Hospital, Innsbruck, Austria. , Hermann ErlerHermann Erler From the Departments of Nuclear Medicine (M.W., E.D., H.E., R.M.) and Internal Medicine (R.G., J.R., M.S.), and the Institute of Biochemical Pharmacology (H.G.), Innsbruck University Hospital, Innsbruck, Austria. , Hartmut GlossmannHartmut Glossmann From the Departments of Nuclear Medicine (M.W., E.D., H.E., R.M.) and Internal Medicine (R.G., J.R., M.S.), and the Institute of Biochemical Pharmacology (H.G.), Innsbruck University Hospital, Innsbruck, Austria. , Josef R. PatschJosef R. Patsch From the Departments of Nuclear Medicine (M.W., E.D., H.E., R.M.) and Internal Medicine (R.G., J.R., M.S.), and the Institute of Biochemical Pharmacology (H.G.), Innsbruck University Hospital, Innsbruck, Austria. , Roy MoncayoRoy Moncayo From the Departments of Nuclear Medicine (M.W., E.D., H.E., R.M.) and Internal Medicine (R.G., J.R., M.S.), and the Institute of Biochemical Pharmacology (H.G.), Innsbruck University Hospital, Innsbruck, Austria. and Michael SchirmerMichael Schirmer From the Departments of Nuclear Medicine (M.W., E.D., H.E., R.M.) and Internal Medicine (R.G., J.R., M.S.), and the Institute of Biochemical Pharmacology (H.G.), Innsbruck University Hospital, Innsbruck, Austria. Originally published18 Feb 2003https://doi.org/10.1161/01.CIR.0000050689.89407.87Circulation. 2003;107:923This previously healthy 81-year-old man with recurrent fever up to 38.8°C and an erythrocyte sedimentation rate of more than 85 mm/h had no pain and did not respond to empirical treatment with antibiotics. Imaging by computerized tomography, thyroid and whole body 99mTc-MIBI scintigraphy (because of pre-diagnosed hyperparathyroidism), gastroscopy, colonoscopy, and bone marrow aspiration were unremarkable. Only whole body 18fluorodeoxyglucose (18F-FDG)-positron emission tomography (PET) revealed markedly increased tracer uptake along the aorta and the adjacent large artery walls (Figure). Fever ceased only hours after the first dose of corticosteroids, which were gradually tapered down during the following weeks. After 3 months, a second 18F-FDG-PET scan showed physiological 18F-FDG uptake in the large vessel walls and increased 18F-FDG uptake in some cervical and upper limb muscles of the right side and the stomach (Figure, F). During a year of follow-up, the patient did well with low-dose corticosteroids and 100 mg azathioprine. Download figureDownload PowerPoint18F-FDG-PET studies show increased 18F-FDG uptake along the large vessel walls before, but not after, corticosteroid treatment. Pretreatment images with coronal, sagittal, and transaxial slices are shown in A, B, and C, respectively, and anterior view and right posterior oblique position are shown in D and E. F, Posttreatment control with anterior view.The editor of Images in Cardiovascular Medicine is Hugh A. McAllister, Jr, MD, Chief, Department of Pathology, St Luke's Episcopal Hospital and Texas Heart Institute, and Clinical Professor of Pathology, University of Texas Medical School and Baylor College of Medicine.Circulation encourages readers to submit cardiovascular images to the Circulation Editorial Office, St Luke's Episcopal Hospital/Texas Heart Institute, 6720 Bertner Ave, MC1-267, Houston, TX 77030.FootnotesCorrespondence to Michael Schirmer, MD, Department of Internal Medicine, Innsbruck University Hospital, A-6020 Innsbruck, Anichstrasse 35. E-mail [email protected] eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsCited By Wenger M and Schirmer M (2022) Indications for diagnostic use of nuclear medicine in rheumatology: A mini-review, Frontiers in Medicine, 10.3389/fmed.2022.1026060, 9 Dejaco C, Duftner C, Dasgupta B, Matteson E and Schirmer M (2011) Polymyalgia rheumatica and giant cell arteritis: management of two diseases of the elderly, Aging Health, 10.2217/ahe.11.50, 7:4, (633-645), Online publication date: 1-Aug-2011. Liozon É, Monteil J, Ly K and Vidal E (2010) Place de la tomographie par émission de positrons (TEP) au [18F]FDG dans l'exploration et la surveillance des vascularites, La Revue de Médecine Interne, 10.1016/j.revmed.2009.06.011, 31:6, (417-427), Online publication date: 1-Jun-2010. Liozon É and Monteil J (2008) Place de la tomographie par émission de positons (TEP) au [18F]FDG dans l'exploration des vascularites, Médecine Nucléaire, 10.1016/j.mednuc.2008.07.003, 32:10, (511-522), Online publication date: 1-Oct-2008. Moncayo R and Moncayo H (2007) A musculoskeletal model of low grade connective tissue inflammation in patients with thyroid associated ophthalmopathy (TAO): the WOMED concept of lateral tension and its general implications in disease, BMC Musculoskeletal Disorders, 10.1186/1471-2474-8-17, 8:1, Online publication date: 1-Dec-2007. Walter M (2007) [18F]Fluorodeoxyglucose PET in Large Vessel Vasculitis, Radiologic Clinics of North America, 10.1016/j.rcl.2007.05.012, 45:4, (735-744), Online publication date: 1-Jul-2007. Walter M (2006) [18F]Fluorodeoxyglucose PET in Large Vessel Vasculitis, PET Clinics, 10.1016/j.cpet.2006.02.001, 1:2, (179-189), Online publication date: 1-Apr-2006. Hickeson M (2006) Infection and Inflammation Pediatric PET Imaging, 10.1007/0-387-34641-4_24, (448-460), . Walter M, Melzer R, Schindler C, Müller-Brand J, Tyndall A and Nitzsche E (2005) The value of [18F]FDG-PET in the diagnosis of large-vessel vasculitis and the assessment of activity and extent of disease, European Journal of Nuclear Medicine and Molecular Imaging, 10.1007/s00259-004-1757-9, 32:6, (674-681), Online publication date: 1-Jun-2005. Schmidt W and Blockmans D (2005) Use of ultrasonography and positron emission tomography in the diagnosis and assessment of large-vessel vasculitis, Current Opinion in Rheumatology, 10.1097/01.bor.0000147282.02411.c6, 17:1, (9-15), Online publication date: 1-Jan-2005. Bleeker-Rovers C, Bredie S, van der Meer J, Corstens F and Oyen W (2004) Fluorine 18 fluorodeoxyglucose positron emission tomography in the diagnosis and follow-up of three patients with vasculitis, The American Journal of Medicine, 10.1016/j.amjmed.2003.07.006, 116:1, (50-53), Online publication date: 1-Jan-2004. February 18, 2003Vol 107, Issue 6 Advertisement Article InformationMetrics https://doi.org/10.1161/01.CIR.0000050689.89407.87PMID: 12591766 Originally publishedFebruary 18, 2003 PDF download Advertisement
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