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Osteophilic Multilayer Coatings for Accelerated Bone Tissue Growth

2012; Volume: 24; Issue: 11 Linguagem: Inglês

10.1002/adma.201104475

1521-4095

Nisarg J. Shah, Jinkee Hong, Md Nasim Hyder, Paula T. Hammond,

Orthopaedic implants and arthroplasty

Advanced MaterialsVolume 24, Issue 11 p. 1445-1450 Communication Osteophilic Multilayer Coatings for Accelerated Bone Tissue Growth Nisarg J. Shah, Nisarg J. Shah Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USASearch for more papers by this authorJinkee Hong, Jinkee Hong Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USASearch for more papers by this authorMd. Nasim Hyder, Md. Nasim Hyder Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USASearch for more papers by this authorPaula T. Hammond, Corresponding Author Paula T. Hammond [email protected] Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USADepartment of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USA.Search for more papers by this author Nisarg J. Shah, Nisarg J. Shah Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USASearch for more papers by this authorJinkee Hong, Jinkee Hong Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USASearch for more papers by this authorMd. Nasim Hyder, Md. Nasim Hyder Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USASearch for more papers by this authorPaula T. Hammond, Corresponding Author Paula T. Hammond [email protected] Department of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USADepartment of Chemical Engineering, The David H. Koch Institute for Integrative Cancer, Research and The Institute for Soldier, Nanotechnologies Massachusetts Institute of Technology 77 Massachusetts Ave, Cambridge, MA 02139 USA.Search for more papers by this author First published: 07 February 2012 https://doi.org/10.1002/adma.201104475Citations: 99Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Osteophilic modular nanostructured multilayers containing hydroxyapatite nanoparticles complexed with a natural polymer chitosan create an osteoconductive surface for mesenchymal stem cells (MSCs). Coupled with the sustained release of physiological amounts of osteoinductive bone morphogenetic protein over several days from degradable poly(β-amino ester) based multilayers, this single coating results in a synergistic accelerated and upregulated differentiation of MSCs into osteoblasts laying down new bone tissue on orthopedic implants. Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. 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